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March 30, 2015

The Neurophysiology of Bipolar Disorder: Clues from Neuroimaging

Bipolar disorder is a leading cause of morbidity worldwide. It is strongly heritable (85%), and the symptoms and signs of bipolar disorder suggest abnormalities within brain systems that control emotional function. These prefrontal-striatal-thalamic iterative networks modulate amygdala, ‘cognitive’ regions of the prefrontal cortex, hypothalamus, and other components of the limbic system. Unfortunately, there are no animal models for bipolar disorder, challenging us to identify approaches toward clarifying its neurophysiology. In the last 10-15 years, magnetic resonance imaging (MRI) techniques have permitted the in vivo exploration of the neurophysiology of bipolar disorder. Structural imaging suggests morphometric abnormalities in emotional networks that progress during adolescence and over time. Functional imaging demonstrates a disconnect in prefrontal modulation of amygdala activation, critical for healthy emotional function. Magnetic resonance spectroscopy suggests metabolic abnormalities in this network as well, particularly in the striatum. As imaging techniques continue to advance, the neurophysiology of bipolar disorder will become even better understood.

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April 7, 2015

C B & I: How Leadership and Core Values Fuel Our Growth

CB&I’s dramatic growth has propelled the company into the most complete energy infrastructure focused company in the world. With 125 years of experience and the expertise of approximately 54,000 employees, CB&I provides reliable and unique solutions across the full spectrum of energy infrastructure. At the center of how CB&I does business are our strong leadership and our core values of safety, ethics and teamwork: Safety: “Nobody gets hurt” is not just a saying – it’s how we create a culture of safety. Ethics: It’s about treating all people with respect, compassion and dignity; empowering our employees and about holding ourselves to the highest possible standard – our employees and customers count on it. Teamwork: The ability of a group of people to do remarkable things hinges on how well those people pull together as a team. Our success stems from our people. Whether it's a Global Day of Caring to give back locally worldwide, or collaborating across business units to create a unique solution, together our employees make all the difference. CB&I’s people have been the source of our innovation and success for 125 years – they are our leaders. Their expertise, experience and commitment are CB&I’s legacy and highlight what our future has to offer. At CB&I we empower all of our talent to be leaders, and as we develop our people, we grow.

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April 22, 2015

Film: "Fixed: The Science/Fiction of Human Enhancement"

There is a growing buzz around the potential for science and technology to create significant "human enhancement" applications, such as bionic limbs, improved memory or cognition, or the ability to choose specific characteristics for our offspring. The possibilities stir the imagination and excitement of many, while for others the rhetoric and current research into human enhancement signals alarms of a new eugenics. And yet, for most non-scientists, this sounds like the realm of science fiction, a world awash in mystery and misunderstanding. Fixed features disability studies scholar Dominika Bednarska; disability justice educator Patty Berne; exoskeleton test pilot Fernanda Castelo; bionics engineer Hugh Herr; NPR radio host John Hockenberry; biochemist and ability studies scholar Gregor Wolbring; robot scientist Rodney Brooks; futurist Jamais Cascio; bioethicist and policy advocate Marcy Darnovsky; braincomputer interface study participant Tim Hemmes; philosophy professor Cressida Heyes; transhumanist James Hughes; reproductive rights advocate Sujatha Jesudason; and disability lawyer Silvia Yee. With cameo performances by some of the world’s leading integrated dance companies, featuring disabled and non-disabled dancers and artists, including the Anjali Dance Company, Antoine Hunter (of Sins Invalid and Urban Jazz Dance Company), AXIS Dance Company, Candoco, Dancing Wheels, GIMP, Kounterclockwise, Lisa Bufano, Marc Brew, Remix Dance Company, and Sue Austin/Freewheeling. Through a dynamic mix of verité, dance, archival and interview footage, Fixed challenges notions of normal, the body and what it means fundamentally to be human in the 21st century.

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