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Basar Bilgicer

Basar Bilgicer

Email: bbilgicer@nd.edu

Phone: 574-631-1429

Office: 205C McCourtney Hall

Education

B.S. Chemistry, Bogazici University, Turkey (1998)

Ph.D. Chemistry, Tufts University, MA (2005)

Biography

Postdoctoral Fellow, Chemistry, Harvard University, MA (2005-2008)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, IN (2008-present)
Assistant Professor, Department of Chemistry and Biochemistry, University of Notre Dame, IN (2008-present)

Publications

Tanyel Kiziltepe, Jonathan D. Ashley, Jared M. Stefanick, Yu Meng Qi, Nathan J. Alves, Michael W. Handlogten, Rudolph Navari, and Basar Bilgicer. "VLA4 Targeting Multifunctional Nanoparticles Overcome Drug Resistance and Inhibit Tumor Growth in Multiple Myeloma". Blood Cancer Journal 2012, 2, e64; doi:10.1038/bcj.2012.10.

Nathan J. Alves, Tanyel Kiziltepe, and Basar Bilgicer. "Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection". Langmuir 2012, doi: 10.1021/la301887s.

Michael W. Handlogten, Tanyel Kiziltepe, Nathan J. Alves and Basar Bilgicer. "Homotetravalent Synthetic Allergen Design Reveals The Significance of Moderate Affinity Epitopes in Mast Cell Degranulation". ACS Chemical Biology 2012, doi: 10.1021/cb300193f.

Nathan J. Alves, Samuel D. Stimple, Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. "A Small Molecule Based Affinity Chromatography Method for Antibody Purification via Nucleotide Binding Site Targeting". Analytical Chemistry 2012, doi: 10.1021/ac300952r.

Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. "A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes". ACS Nano 2013; 7 (4); 2935–2947.

Haihua Xiao, Jared Stefanick, Xiaoyu Jia, Xiabin Jing, Tanyel Kiziltepe, Yu Zhang, and Basar Bilgicer. "Micellar Nanoparticle Formation via Electrostatic Interactions for Delivering Multinuclear Platinum (II) Drugs". ChemComm 2013; doi:10.1039/C3CC39119A.

Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shaw, Rudolph M. Navari, Tanyel Kiziltepe and Basar Bilgicer. "Selective Photocrosslinking of Functional Ligands to Antibodies via the Conserved Nucleotide Binding Site". Biomaterials 2013, doi: 10.1016/j.biomaterials.2013.03.082.

Jared Stefanick, Jonathan Ashley, and Basar Bilgicer. "Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles Through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length". ACS Nano 2013; 7 (9); 8115–8127.

Michael W. Handlogten, Tanyel Kiziltepe, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. "Selective Inhibition of Weak-Affinity Epitope-IgE Interactions via Heterobivalent Inhibitor Design Prevents Mast Cell Degranulation". Nature Chemical Biology 2013, doi: 10.1038/nchembio.1358.

Summary of Activities/Interests

Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).

Basar Bilgicer is fighting to cure food allergies. To support this important research, visit SupportingNotreDame.


News

Novel Platform Uses Nanoparticles to Detect Peanut Allergies

June 27, 2017

Researchers in Notre Dame's Department of Chemical Engineering have developed a novel platform to more accurately detect and identify the presence and severity of peanut allergies, without directly exposing patients to the allergen.

Notre Dame Researchers Are Improving the Speed and Practicality of Detecting Disease

June 15, 2017

To improve the speed and practicality of common diagnostic tests, Notre Dame researchers have been working to develop an improved test method and have recently published a study on a new method that uses gold nanoparticles, requires little to no expertise, and provides results in minutes.

Fighting to Cure Food Allergies

September 14, 2016

Professor Basar Bilgicer hopes to make allergies, and the accompanying anxiety and trauma, a thing of the past. For an aspiration that large, he had to start small. Biomolecular small.

Fighting to Cure Food Allergies

September 12, 2016

Professor Basar Bilgicer hopes to make allergies, and the accompanying anxiety and trauma, a thing of the past. For an aspiration that large, he had to start small. Biomolecular small.

Taking Multiple Myeloma Down for the Count

July 7, 2016

When battling cancer, everything is on the table. Radiation therapy. Surgery. Chemo. Advances in nanotechnology have enabled researchers, like Associate Professor Z. Basar Bilgicer, Research Assistant Professor Tanyel Kiziltepe, and their team in the Department of Chemical and Biomolecular Engineering at the University of Notre Dame, to encapsulate cancer-fighting/cancer-killing drugs into nanoparticles that can deliver therapeutic drugs directly to the site of a tumor, effectively avoiding healthy tissue and minimizing adverse reactions.