Summary of Activities/Interests
Postdoctoral Fellow, Chemistry, Harvard University, MA (2005-2008)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, IN (2008-present)
Assistant Professor, Department of Chemistry and Biochemistry, University of Notre Dame, IN (2008-present)
B.S. Chemistry, Bogazici University, Turkey (1998)
Ph.D. Chemistry, Tufts University, MA (2004)
Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).
Natascha Naarmann, Başar Bilgiçer, He Meng, Krishna Kumar and Claudia Steinem. Fluorinated Interfaces Drive Self Association of Transmembrane Helices in Lipid Bilayers. Angewandte Chemie International Edition, 45:2588-2591, 2006.
Başar Bilgiçer, Demetri T. Moustakas, and George M. Whitesides. A synthetic trivalent hapten that aggregates anti-2,4-DNP IgG into bicyclic trimers. Journal of The American Chemical Society, 129:3722-3728, 2007.
Başar Bilgiçer and Krishna Kumar. De Novo Design of Defined Helical Bundles in Membrane Environments. Proceedings in the National Academy of Sciences, 101:15324-15329, 2004.
Başar Bilgiçer, Samuel W. Thomas III, Bryan F. Shaw, George K. Kaufman, Vijay M. Krishnamurthy, Lara A. Estroff, Jerry Yang and George M. Whitesides. A Non-Chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids. Journal of The American Chemical Society, 131:9361-9367, 2009.