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Hsueh-Chia Chang

Hsueh-Chia Chang


Phone: 574-631-5697

Office: 118B Cushing Hall


Ph.D, Princeton University, 1980

M.S., Princeton University, 1977

B.S., California Institute of Technology, 1976


Assistant Professor, University of California, Santa Barbara (1980-1983)
Associate Professor, University of California, Santa Barbara (1983-84)
Associate Professor, University of Houston (1984-1987)
Professor, University of Notre Dame (1987-1998)
Chair, Chemical Engineering, University of Notre Dame (1989-1995)
Senior Visitor, DAMTP, Cambridge University (1993)
Bayer Professor, University of Notre Dame (1998-Present)
Director, Center for Microfluidics and Medical Diagnostics (2003-Present)

Prof Chia Chang, the Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics, is a leading researcher in micro/nanofluidics, particularly in the area of nano-electrokinetics. He has just published a Cambridge Univ Press book on the subject. His group combines analysis and physical insight to discover new physical phenomena and to develop patented devices for technology transfer. More than 20 of his former PhD students are now teaching in leading academic universities throughout the world. Prof Chang is the founding Editor of Biomicrofluidics, an American Institute of Physics journal. He has received many awards including the Frankiel Award from the American Physical Society and the Presidential Young Investigator Award from NSF. A fellow of APS, he has delivered more than 20 keynote/plenary lectures and has more than 200 publications with over 3000 citations.

Professional Activities

Chief Scientific Advisor, FCubed LLC, with 10 employees
Author of “Complex Wave Dynamics on Falling Films”, Elsevier Press (2002)
Chief and founding Editor: Biomicrofludics 2006 (2011 Impact Factor: 3.895)
Author of “Electrokinetically Driven Microfluidics and Nanofluidics”, Cambridge Uni Press (2009)
Inaugural Steering Committee, Advanced Diagnostics and Therapeutics Initiative Notre Dame (2009)
Founder, Advances in Microfluidics and Nanofluidcs AMN Conference at Hong Kong, Singapore, Dalian and Notre Dame (2009-2013)
Director, Center for Microfluidics and Medical Diagnostics to initiate tech transfer activities at Notre Dame (2003-Present)


I.-F. Cheng, X. Cheng, S. Basuray, and H.-C. Chang. "A Rapid Field-Use Assay for Mismatch Number and Location of Hybridized DNA's". Lab-on-a-Chip, 10:828-831, 2010.

S. Basuray, S. Ajian, A. Mahon, A.R. and H.-C. Chang. "Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive and Mismatch-Discriminating DNA Hybridization". ACS Nano, 3:1823, 2009.


Regent's Junior Faculty Award, University of California, Santa Barbara (1980)

Presidential Young Investigator, National Science Foundation (1985)

Colburn Lectureship, University of Delaware (1988)

Sigma Chi Faculty Research Award, University of Notre Dame (1990)

Francois N. Frenkiel Award, American Physical Society (1991)

Pattern Lectureship, University of Colorado (1992)

Fellow, American Physical Society (1997)

Corrsin Hydrodynamics Lecture, Johns Hopkins (2002)

United Kingdom Royal Society of Engineering Distinguished Professorship (2011)

1st Source Commercialization Award, Notre Dame (2013)

Summary of Activities/Interests

We explore and apply electrokinetic phenomena to develop new diagnostic and micro/nanofluidic devices that are portable, sensitive and fast. We are particularly interested in designing new molecular sensing and analysis technologies based on AC and non-equilibrium electrokinetics at the surface of nanoporous membranes and nanostructure assemblies. Devices and techniques under development include DNA/RNA sensing, on-chip pH actuation, Carbon Nanotube/Nanocolloid molecular sensors, nanofuidic diodes, plasmonic sensors etc. Three technologies have been licensed to FCubed LLC of Notre Dame Innovation Park and we are integrating them into diagnostic devices for environmental, medical and food safety applications.


Notre Dame, U.S. Navy to Collaborate on New Tool to Diagnose Infectious Diseases

November 19, 2014

Researchers from the University of Notre Dame and the Naval Medical Research Center have signed a Cooperative Research and Development Agreement to collaborate on a new field-deployable sensor for the detection of infectious disease pathogens, with initial focus on the detection of dengue fever.

Cancer Detection Test Takes Grand Prize in Notre Dame Business Plan Competition

April 14, 2014

In February 2014 the College of Engineering announced that NanDio, a team of students, took first place in the 2014 Brown-Forman Cardinal Challenge. Today, they claimed top prize in the Mendoza College of Business' 15th McCloskey Business Plan Competition.

ND Team Takes Top Prize in 2014 Cardinal Challenge

February 18, 2014

NanDio, a team of students from the University of Notre Dame, took first place in the 2014 Brown-Forman Cardinal Challenge held February 14-15 by the University of Louisville College of Business. The team was honored for its business plan to commercialize an oral cancer detection device for dentists. All teams were judged on their written plan, the poise and professionalism of their presentation, and the viability of their venture. The NanDio device’s simplicity of use, speed of test results and accuracy of the test as an early detector gave the team the winning edge.

Notre Dame Engineering Team Receives NSF I-Corps Award for Innovation Training

April 23, 2013

A team from the University of Notre Dame has been awarded a $50,000 National Science Foundation (NSF) Innovation Corps (I-Corps) award to perform a commercialization assessment of a diagnostic technology that resulted from prior NSF-funded research coming out of the Advanced Diagnostics and Therapeutics Initiative (AD&T). The I-Corps program was established in 2011 to help jump-start a national innovation ecosystem by providing entrepreneurial training to more effectively move technologies out of the lab and into the marketplace.

Prof. Chang and FCubed in Chicago Sun Times

November 30, 2012

"Entering new waters via tiny chip" article by Sandra Guy appeared in the Chicago Sun Times on November 12, 2012. Find the full article and video at Prof Chang's lab, the Center for Microfluidics and Medical Diagnostics, invented the Carbon Nanotube Sensor for the first portable nucleic acid (DNA and RNA) diagnostic device now being produced by FCubed, LLC.

USDA Funds Development of a New Test for Safer Milk

June 29, 2012

A team of researchers from the University of Notre Dame and Purdue University has received a three-year grant of $500,000 from the U.S. Department of Agriculture to develop a new technology that can rapidly test milk and other dairy products for harmful pathogens.

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