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Hsueh-Chia Chang

Hsueh-Chia Chang

Contact Info

Phone: 574-631-5697
Office: 118B Cushing Hall
Curriculum Vitae

Summary of Activities/Interests

We explore and apply electrokinetic phenomena to develop new diagnostic and micro/nanofluidic devices that are portable, sensitive and fast. We are particularly interested in designing new molecular sensing and analysis technologies based on AC and non-equilibrium electrokinetics at the surface of nanoporous membranes and nanostructure assemblies. Devices and techniques under development include DNA/RNA sensing, on-chip pH actuation, Carbon Nanotube/Nanocolloid molecular sensors, nanofuidic diodes, plasmonic sensors etc. Three technologies have been licensed to FCubed LLC of Notre Dame Innovation Park and we are integrating them into diagnostic devices for environmental, medical and food safety applications.


B.S. Caltech (1976)

M.S. Princeton (1977)

Ph.D. Princeton (1980)


Assistant Professor, University of California, Santa Barbara (1980-1983)
Associate Professor, University of California, Santa Barbara (1983-84)
Associate Professor, University of Houston (1984-1987)
Professor, University of Notre Dame (1987-1998)
Chair, Chemical Engineering, University of Notre Dame (1989-1995)
Senior Visitor, DAMTP, Cambridge University (1993)
Bayer Professor, University of Notre Dame (1998-Present)
Director, Center for Microfluidics and Medical Diagnostics (2003-Present)

Prof Chia Chang, the Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics, is a leading researcher in micro/nanofluidics, particularly in the area of nano-electrokinetics. He has just published a Cambridge Univ Press book on the subject. His group combines analysis and physical insight to discover new physical phenomena and to develop patented devices for technology transfer. More than 20 of his former PhD students are now teaching in leading academic universities throughout the world. Prof Chang is the founding Editor of Biomicrofluidics, an American Institute of Physics journal. He has received many awards including the Frankiel Award from the American Physical Society and the Presidential Young Investigator Award from NSF. A fellow of APS, he has delivered more than 20 keynote/plenary lectures and has more than 200 publications with over 3000 citations.

Professional Activities

Chief Scientific Advisor, FCubed LLC, with 10 employees
Author of “Complex Wave Dynamics on Falling Films”, Elsevier Press (2002)
Chief and founding Editor: Biomicrofludics 2006 (2011 Impact Factor: 3.895)
Author of “Electrokinetically Driven Microfluidics and Nanofluidics”, Cambridge Uni Press (2009)
Inaugural Steering Committee, Advanced Diagnostics and Therapeutics Initiative Notre Dame (2009)
Founder, Advances in Microfluidics and Nanofluidcs AMN Conference at Hong Kong, Singapore, Dalian and Notre Dame (2009-2013)
Director, Center for Microfluidics and Medical Diagnostics to initiate tech transfer activities at Notre Dame (2003-Present)


I.-F. Cheng, X. Cheng, S. Basuray, and H.-C. Chang. "A Rapid Field-Use Assay for Mismatch Number and Location of Hybridized DNA's". Lab-on-a-Chip, 10:828-831, 2010.

S. Basuray, S. Ajian, A. Mahon, A.R. and H.-C. Chang. "Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive and Mismatch-Discriminating DNA Hybridization". ACS Nano, 3:1823, 2009.


Regent's Junior Faculty Award, University of California, Santa Barbara (1980)

Presidential Young Investigator, National Science Foundation (1985)

Colburn Lectureship, University of Delaware (1988)

Sigma Chi Faculty Research Award, University of Notre Dame (1990)

Francois N. Frenkiel Award, American Physical Society (1991)

Pattern Lectureship, University of Colorado (1992)

Fellow, American Physical Society (1997)

Corrsin Hydrodynamics Lecture, Johns Hopkins (2002)

United Kingdom Royal Society of Engineering Distinguished Professorship (2011)

1st Source Commercialization Award, Notre Dame (2013)