College of Engineering
Office: MRB 142
Ph.D., Mechanical Engineering, Georgia Institute of Technology (2011)
M.S., Mechanical Engineering, Georgia Institute of Technology (2009)
B.S., Mechanical Engineering, Grove City College (2006)
Assistant Professor, Department of Aerospace and Mechanical Engineering, University of Notre Dame (2014-present)
Ruth L. Kirschstein Postdoctoral Fellow, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic (2011-2014)
Graduate Research Assistant, George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology (2006-2011)
- Boerckel JD, Kolambkar YM, Stevens HY, Lin ASP, Dupont KM, Guldberg RE, “Effects of in Vivo Mechanical Loading on Large Bone Defect Regeneration.” Journal of Orthopaedic Research. 2012 Jul;30(7):1067-75.
- Berner A*, Boerckel JD*, Saifzadeh S, Steck R, Ren J, Vaquette C, Zhang JQ, Nerlich M, Guldberg RE, Hutmacher DW, Woodruff MA. “Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration.” Cell and Tissue Research. 2012 Mar;347(3):603-12. *Contributed equally.
- Boerckel JD, Uhrig BA, Willett, NJ, Huebsch N, Guldberg RE, “Mechanical Regulation of Vascular Growth and Tissue Regeneration in Vivo.” Proceedings of the National Academy of Sciences. 2011 Sep 13;108(37):E674-80.
- Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, García AJ, Guldberg RE, “Effects of Protein Dose and Delivery System on BMP-Mediated Bone Regeneration. Biomaterials. 2011 Aug;32(22):5241-51.
- Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE, “In Vivo Model for Evaluating the Effects of Mechanical Stimulation on Tissue-Engineered Bone Repair,” Journal of Biomechanical Engineering. 2009 Aug;131(8):084502.
Summary of Activities/Interests
The human body has remarkable potential for self-regeneration, but often these processes are insufficient or break down, resulting in disease, debilitation, or insufficient healing after injury. The Tissue Engineering and Mechanobiology Lab at Notre Dame aims to characterize, stimulate, and augment these endogenous repair mechanisms to engineer new tissues through three complimentary points of intervention: Biomaterials, Biomechanics, and Biology.
Biomaterials. We develop and characterize biomaterials that serve as biomimetic scaffolds on which new tissues can form and as vehicles for controlled delivery of biologic agents, such as growth factors.
Biomechanics. Unlike typical engineering materials, our cells and tissues have the capability to sense mechanical stimuli and alter their own properties in response through a process called mechanical adaptation. We are developing methods to quantify and harness this power for regenerative purposes.
Biology. We aim to elucidate the mechanisms by which cells sense their mechanical environment (mechanobiology) and cross-talk with other cell types (ie. bone cells and vascular cells) to control regeneration.
The Tissue Engineering and Mechanobiology lab is always seeking motivated students interested in tissue engineering, biomechanics, and mechanobiology to pursue our research mission. Prospective graduate students should apply to the Graduate School (graduateschool.nd.edu) prior to contacting Dr. Boerckel at jboercke@ND.edu.