Summary of Activities/Interests
Developing new strategies for building tissues and treating degenerative tissue diseases requires investigating animal development from an engineering perspective. Probing animal development with quantitative tools can potentially improve traditional methods of tissue engineering as well as inspire completely novel methods for creating synthetic organs. In the Zartman lab, we are focused on the systematic analysis of chemical and mechanical signaling at the tissue scale, including developing computational models of how cells self-organize into organs of the correct shape and size. We address these questions using experiments and modeling in systems such as Drosophila that are amenable to sophisticated genetic approaches, live imaging and in vitro culture. The main objective of the lab is to synthesize mechanistic models of two fundamental processes during development: 1. the control of organ growth, and 2. the organization of cellular sheets into three-dimensional structures.
Chemical and biological engineers can contribute significantly toward understanding how organ size and shape are regulated by utilizing a diverse toolkit of skills: solving reaction-diffusion and transport problems, utilizing control and decision theory toward the reverse engineering of transcriptional networks, applying quantitative and statistical methods in the optimization of next-generation growth media for organ development in vitro, and employing experimental knowledge in the analysis of soft materials.
Ph.D., Chemical Engineering, Princeton University (2009)
M.A., Chemical Engineering, Princeton University (2006)
B.S., Chemical Engineering and Engineering Physics, University of Colorado at Boulder (2004)
Research Assistant, Dep. of Mech. Eng. and Membrane Applied Science & Technology Center, Univ. of Colorado, Boulder, CO (1999-2002)
REU participant, University of Colorado-Boulder, Boulder, CO (2000)
REU Research Assistant, M.I.T., Cambridge, MA (2002)
Research Assistant, University of Colorado, Boulder, CO (2004)
Postdoctoral Research Scientist, University of Zurich, Switzerland (2009-2011)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN (2012-present)
Member, American Institute of Chemical Engineers
Member, Genetics Society of America
Affiliated with Advanced Diagnostics and Therapeutics (AD&T) at the University of Notre Dame
Affiliated with the Mike and Josie Harper Cancer Research Institute (University of Notre Dame/Indiana School of Medicine South Bend)
Zartman J*, Restrepo S*, Basler K A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development 2013 Feb;140(3):667–674.
N. Yakoby, C. A. Bristow, D. Gong, X. Schafer, J. Lembong, J. J. Zartman, M. S. Halfon, T. Schupbach and S. Y. Shvartsman. Dev Cell 15, 5:725-737, 2008.
J. J. Zartman, J. S. Kanodia, N. Yakoby, X. Schafer, C. Watson, K. Schlichting, C. Dahmann, and S. Y. Shvartsman. Development, 17:2903-2911, 2009.
J. J. Zartman, L. S. Cheung, M. G. Niepielko, C. Bonini, B. Haley, N. Yakoby and S. Y. Shvartsman. Phys. Biol., 4:18947, 2011.
J. J. Zartman and S. Y. Shvartsman. Annual Review of Chemical and Biomolecular Engineering, 1:231-246, 2010.
S.-J. Yan, J. J. Zartman, M. Zhang,A. Scott, S. Y. Shvartsman and W. X. Li. Molecular Systems Biology, 5:278, 2009.
J. J. Zartman, J. S. Kanodia, N. Yakoby, X. Schafer, C. Watson, K. Schlichting, C. Dahmann and S. Y. Shvartsman. Gene Expr Patterns, 1:31-36, 2009.
Long-term EMBO postdoctoral fellowship (2010-2011)
Received February 1, 2010
Schering-Plough Science and Innovation Award
Received March 3, 2008
Princeton Hertz Fellowship (2004-2009)
Received September 1, 2004