Ph.D., Chemical Engineering, Princeton University, 2009
M.A., Chemical Engineering, Princeton University, 2006
B.S., Chemical Engineering and Engineering Physics, University of Colorado at Boulder, 2004
Research Assistant, Dep. of Mech. Eng. and Membrane Applied Science & Technology Center, Univ. of Colorado, Boulder, CO (1999-2002)
REU participant, University of Colorado-Boulder, Boulder, CO (2000)
REU Research Assistant, M.I.T., Cambridge, MA (2002)
Research Assistant, University of Colorado, Boulder, CO (2004)
Postdoctoral Research Scientist, University of Zurich, Switzerland (2009-2011)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN (2012-present)
Member, American Institute of Chemical Engineers
Member, Genetics Society of America
Affiliated with Advanced Diagnostics and Therapeutics (AD&T) at the University of Notre Dame
Affiliated with the Mike and Josie Harper Cancer Research Institute (University of Notre Dame/Indiana School of Medicine South Bend)
Burnette M., Brito-Robinson T., Li J., Zartman J. An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines. Mol BioSyst (2014), DOI: 10.1039/C4MB00155A.
Buchmann A, Alber M, Zartman JJ, Sizing it up: The mechanical feedback hypothesis of organ growth regulation, Seminars in Cell and Developmental Biology (2014), http://dx.doi.org/10.1016/j.semcdb.2014.06.018.
Restrepo, S*, Zartman, JJ*, Basler, K. Coordination of Patterning and Growth by the Morphogen DPP. Curr. Biol. 24, R245–R255 (2014).
Zartman J*, Restrepo S*, Basler K. (2013) A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development. Feb;140(3):667–674.
Zartman JJ*, Cheung LS*, Niepielko MG, Bonini C, Haley B, Yakoby N, Shvartsman SY (2011). Pattern formation by a moving morphogen source. Phys Biol. Aug;8(4):045003. 2012
Zartman JJ and Shvartsman SY (2010). Unit Operations of Tissue Development: Epithelial Folding. Annual Review of Chemical and Biomolecular Engineering 1:231-46.
Zartman JJ, Kanodia JS, Cheung LS, Shvartsman SY (2009) Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis. Development 136(17):2903-2911.
Yan S-J, Zartman JJ, Zhang M, Scott A, Shvartsman SY, Li WX. (2009) Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Molecular Systems Biology 5:278.
Zartman JJ, Kanodia JS, Yakoby N, Schafer X, Watson C, Schlichting K, Dahmann C, Shvartsman SY (2009) Expression patterns of cadherin genes in Drosophila oogenesis. Gene Expr Patterns 9(1):31-36.
Yakoby N, Bristow CA, Gong D, Schafer X, Lembong J, Zartman JJ, Halfon MS, Schupbach T, Shvartsman SY (2008) A Combinatorial Code for Pattern Formation in Drosophila Oogenesis. Dev Cell 15(5):725-737.
Zartman JJ, Yakoby N, Bristow CA, Zhou X, Schlichting K, Dahmann C and Shvartsman, SY (2008) Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis. Developmental Biology 322:289-301.
Zartman JJ, and Shvartsman SY (2007) Enhancer organization: transistor with a twist or something in a different vein? Curr Biol 17(24):R1048-1050.
Pekny M, Zartman J, Krantz W, Greenberg A, Todd, P. (2003) Flow-visualization during macrovoid pore formation in dry-cast cellulose acetate membranes. J Memb Sci 211:71-90.
Khare V, Greenberg A, Zartman J, Krantz W, Todd P (2002) Macrovoid growth during polymer membrane casting. Desalination 145:17-23.
Pekny MR, Zartman J, Greenberg AR, Krantz, WB, Todd P (2002) Macrovoid pore formation in dry-east cellulose acetate membranes: buoyancy studies. J Memb Sci 205:11-21.
Long-term EMBO postdoctoral fellowship (2010-2011)
Received February 1, 2010
Schering-Plough Science and Innovation Award
Received March 3, 2008
Princeton Hertz Fellowship (2004-2009)
Received September 1, 2004
Summary of Activities/Interests
Developing new strategies for building tissues and treating degenerative tissue diseases requires investigating animal development from an engineering perspective. Probing animal development with quantitative tools can potentially improve traditional methods of tissue engineering as well as inspire completely novel methods for creating synthetic organs. In the Zartman lab, we are focused on the systematic analysis of chemical and mechanical signaling at the tissue scale, including developing computational models of how cells self-organize into organs of the correct shape and size. We address these questions using experiments and modeling in systems such as Drosophila that are amenable to sophisticated genetic approaches, live imaging and in vitro culture. The main objective of the lab is to synthesize mechanistic models of two fundamental processes during development: 1. the control of organ growth, and 2. the organization of cellular sheets into three-dimensional structures.
Chemical and biological engineers can contribute significantly toward understanding how organ size and shape are regulated by utilizing a diverse toolkit of skills: solving reaction-diffusion and transport problems, utilizing control and decision theory toward the reverse engineering of transcriptional networks, applying quantitative and statistical methods in the optimization of next-generation growth media for organ development in vitro, and employing experimental knowledge in the analysis of soft materials.
September 3, 2014