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Ryan K. Roeder

Affiliations

College of Engineering Associate Professor

Summary of Activities/Interests

Biomaterials, Nanoparticles, Scaffolds, Composites, Bone Mechanics

Education

Ph.D. Materials Engineering - Purdue University, 1999

Biography

Dr. Roeder's research interests broadly span biomaterials, including scaffolds for regenerating tissues and nanoparticles for targeted contrast agents and drug delivery, as well biomechanics, including the mechanobiology and micromechanics of musculoskeletal tissues.  Dr. Roeder's research has been supported by the National Science Foundation (NSF), the National Institutes of Health (NIH), the U.S. Army Medical Research and Materiel Command (USAMRMC), the Congressionally-Directed Medical Research Programs (CDMRP), as well as private foundations and corporations.  Dr. Roeder’s research group is multidisciplinary, including students with backgrounds in mechanical engineering, materials engineering, bioengineering, chemical engineering and chemistry.  Ph.D. graduates have been placed in postdoctoral positions, research hospitals, biomedical industry positions, and faculty positions.

Selected Recent Publications

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of breast microcalcifications in a murine model using targeted gold nanoparticles,” ACS Nano, 8 [7], 7486-7496 (2014). doi:10.1021/nn5027802

T.L. Turnbull, A.P. Baumann, and R.K. Roeder, “Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization,” J. Biomechanics, in press. doi:10.1016/j.jbiomech.2014.06.022

R.D. Ross, L.E. Cole, J.M.R. Tilley and R.K. Roeder, “Effect of Functionalized Gold Nanoparticle Size on X-Ray Attenuation and Binding Affinity to Hydroxyapatite,” Chem. Mater., 26 [2], 1187-1194 (2014). doi:10.1021/cm4035616

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Bisphosphonate-functionalized gold nanoparticles for contrast-enhanced X-ray detection of breast microcalcifications,” Biomaterials, 35 [7] 2312-2321 (2014). doi:10.1016/j.biomaterials.2013.11.077

M.J. Meagher, B. Leone, T.L. Turnbull, R.D. Ross, Z. Zhang and R.K. Roeder, “Dextran-encapsulated barium sulfate nanoparticles prepared for aqueous dispersion as an X-ray contrast agent,” J. Nanopart. Res., 15 [12] 2146 (10 pages) (2013). doi:10.1007/s11051-013-2146-8

R.K. Roeder, “Mechanical Characterization of Biomaterials”; in Characterization of Biomaterials.  Edited by A. Bandyopadhyay and S. Bose.  Elsevier, Inc., Amsterdam, 2013.  doi:10.1016/B978-0-12-415800-9.00003-6

T.L. Conrad, D.J. Jaekel, S.M. Kurtz and R.K. Roeder, “Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker reinforced polyetheretherketone scaffolds,” J. Biomed. Mater. Res., 101B [4] 576-583 (2013). doi:10.1002/jbm.b.32859

R.K. Roeder and T.L. Conrad, “Bioactive Polyaryletherketone Composites”; pp. 163-179 in the PEEK Biomaterials Handbook. Edited by S.M. Kurtz.  Elsevier, Inc., Amsterdam, 2012. doi:10.1016/B978-1-4377-4463-7.10011-9

A.P. Baumann, J.M. Deuerling, D.J. Rudy, G.L. Niebur and R.K. Roeder, “The relative influence of apatite crystal orientations and intracortical porosity on the elastic anisotropy of human cortical bone,” J. Biomechanics, 45 [16] 2743-2749 (2012). doi:10.1016/j.jbiomech.2012.09.011

R.J. Kane and R.K. Roeder, “Effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds,” J. Mech. Behav. Biomed. Mater.7, 41-49 (2012). doi:10.1016/j.jmbbm.2011.09.010

R.D. Ross, L.E. Cole and R.K. Roeder, “Relative binding affinity of carboxylate-, phosphonate-, and bisphosphonate-functionalized gold nanoparticles targeted to damaged bone tissue,” J. Nanopart. Res., 14 [10] 1175 (11 pages) (2012). doi:10.1007/s11051-012-1175-z

R.J. Kane and R.K. Roeder, “Effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds,” J. Mech. Behav. Biomed. Mater., 7, 41-49 (2012). doi:10.1016/j.jmbbm.2011.09.010