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Ryan Roeder

Ryan K. Roeder


Phone: 574-631-7003

Office: 148 Multidisciplinary Building


B.S., Materials Engineering - Purdue University, 1994

Ph.D. Materials Engineering - Purdue University, 1999


Dr. Roeder's research interests broadly span biomaterials, including nanoparticles for targeted contrast agents and drug delivery, and scaffolds for regenerating tissues, as well biomechanics, including the mechanobiology and micromechanics of musculoskeletal tissues.  Dr. Roeder's research has been supported by the National Science Foundation (NSF), the National Institutes of Health (NIH), the U.S. Army Medical Research and Materiel Command (USAMRMC), the Congressionally-Directed Medical Research Programs (CDMRP), the Defense Advanced Research Projects Agency (DARPA), as well as a number of private foundations and corporations.  Dr. Roeder’s research group is multidisciplinary, including students with backgrounds in biomedical engineering, materials engineering, mechanical engineering, chemical engineering, and chemistry.  Ph.D. graduates have been placed in postdoctoral positions, research hospitals, biomedical industry positions, and faculty positions.

Selected Recent Publications

P.D. Nallathamby, J. Hopf, L.E. Irimata, T.L. McGinnity and R.K. Roeder, “Preparation of fluorescent Au-SiO2 core-shell nanoparticles and nanorods with tunable silica shell thickness and surface modification for immunotargeting,” J. Mater. Chem. B, in press. doi:10.1039/c6tb01659f

T.L. McGinnity, O. Dominguez, T.E. Curtis, P.D. Nallathamby, A.J. Hoffman and R.K. Roeder, “Hafnia (HfO2) nanoparticles as an X-ray contrast agent and mid-infrared biosensor,” Nanoscale, 8, 13627-13637 (2016). doi:10.1039/c6nr03217f

M.J. Meagher, H.E. Weiss-Bilka, M.E. Best, D.R. Wagner and R.K. Roeder, “Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction,” J. Biomed. Mater. Res., 104A, 2178-2188 (2016). doi:10.1002/jbm.a.35760

L.C. Cole, T. Vargo-Gogola and R.K. Roeder, “Targeted delivery to bone and mineral deposits using bisphosphonate ligands,” Adv. Drug Deliv. Rev., 99, 12-27 (2016). doi:10.1016/j.addr.2015.10.005

A.P. Baumann, X. Shi, R.K. Roeder and G.L. Niebur, “The sensitivity of nonlinear computational models of trabecular bone to tissue level constitutive model,” Comput. Methods Biomech. Biomed. Eng., 19 [5] 465-473 (2015). doi:10.1080/10255842.2015.1041022

M.D. Hunckler, J.M.R. Tilley and R.K. Roeder, “Molecular Transport in Collagenous Tissues Measured by Gel Electrophoresis,” J. Biomechanics, 48 [15] 4087-4092 (2015). doi:10.1016/j.jbiomech.2015.10.006

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of microcalcifications in radiographically dense mammary tissue using targeted gold nanoparticles,” ACS Nano, 9 [9] 8923-8932 (2015). doi:10.1021/acsnano.5b02749  Press release.

A.P. Baumann, M.W. Aref, T.L. Turnbull, A.G. Robling, G.L. Niebur, M.R. Allen and R.K. Roeder, “Development of an In Vivo Rabbit Ulnar Loading Model,” Bone, 75, 55-61 (2015). 10.1016/j.bone.2015.01.022

R.J. Kane, H.E. Weiss-Bilka, M.J. Meagher, Y. Liu, J.A. Gargac, G.L. Niebur, D.R. Wagner and R.K. Roeder, “Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties,” Acta Biomaterialia, 17, 16-25 (2015). doi:10.1016/j.actbio.2015.01.031

L.E. Cole, R.D. Ross, J.M.R. Tilley, T. Vargo-Gogola and R.K. Roeder, “Gold nanoparticles as contrast agents in X-ray imaging and computed tomography,” Nanomedicine, 10 [2] 321-341 (2015). doi:10.2217/nnm.14.171

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of breast microcalcifications in a murine model using targeted gold nanoparticles,” ACS Nano, 8 [7], 7486-7496 (2014). doi:10.1021/nn5027802

T.L. Turnbull, A.P. Baumann and R.K. Roeder, “Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization,” J. Biomechanics, 47 [12] 3135-3142 (2014). doi:10.1016/j.jbiomech.2014.06.022

R.D. Ross, L.E. Cole, J.M.R. Tilley and R.K. Roeder, “Effect of Functionalized Gold Nanoparticle Size on X-Ray Attenuation and Binding Affinity to Hydroxyapatite,” Chem. Mater., 26 [2], 1187-1194 (2014). doi:10.1021/cm4035616

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Bisphosphonate-functionalized gold nanoparticles for contrast-enhanced X-ray detection of breast microcalcifications,” Biomaterials, 35 [7] 2312-2321 (2014). doi:10.1016/j.biomaterials.2013.11.077

Summary of Activities/Interests

Biomaterials, Biomechanics, Materials Science, Mechanical Behavior, Nanoparticles, Scaffolds


ND Research Announces 2016 Internal Grant Awardees

May 4, 2016

Notre Dame Research has provided more than 35 researchers with awards from the Internal Grants Program for 2016.

Dr. Prakash Nallathamby wins Pfizer Young Investigator Poster Award

November 5, 2015

Postdoctoral Research Associate Prakash Nallathamby was awarded a Pfizer Young Investigator Poster Award during a recent retreat held by the Cancer Biology Training Consortium Symposium.

Researchers Use Nanotechnology to Fight Breast Cancer

October 9, 2015

October is Breast Cancer Awareness Month, an annual campaign to increase awareness of the disease and the importance of early detection. Researchers at the University of Notre Dame are conducting innovative research aimed at improvements in early detection by molecular imaging.

The Transformation of Cancer Imaging: From Shades of Gray to Living Color

September 30, 2015

Promising a transformation in biomedical imaging, a new technology called spectral [color] computed tomography is at work on the University of Notre Dame’s campus, where researchers are giving the phrase “in living color” a new meaning.

New Approach to Mammograms Could Improve Reliability

September 18, 2015

A recent article in the journal ASC Nano describes a process using targeted gold nanoparticles: "Detecting breast cancer in women with dense mammary tissues could become more reliable with a new mammogram procedure that researchers have now tested in pre-clinical studies of mice."