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Tanyel Kiziltepe

Tanyel Kiziltepe

Assistant Research Professor

Department of Chemical and Biomolecular Engineering

Assistant Research Professor
College of Engineering

Email: tkiziltepe@nd.edu

Phone: 574-631-1603

Office: 105 Cushing Hall

Education

B.S. Chemistry, Bilkent University, Turkey (1998)

Ph.D. Biological Chemistry, Massachusetts Institute of Technology, MA (2004)

Biography

Postdoc Fellow, Dana Farber Cancer Institute, MA (2005-2007)
Faculty, Harvard Medical School, MA (2005-2007)
Scientist, Cerulean Pharmaceuticals, MA (2007-2008)
Assistant Research Professor, University of Notre Dame, IN (2008-present)

Publications

Kiziltepe T, Hideshima T, Catley L, Raje N, Yasui H, Vallet S, Okawa Y, Ikeda H, Ishitsuka K, Shiraishi N, Chauhan D, Anderson KC. 5-Azacytidine, a DNA Methyltransferase Inhibitor, Induces ATR Mediated DNA Double Strand Break Responses, Apoptosis, and Synergistic Cytotoxicity with Doxorubicin and Bortezomib against Multiple Myelo. Mol Cancer Ther., 6(6):1718-27, 2007.

Kiziltepe T, Hideshima T, Ishitsuka K, Ocio EM, Raje N, Catley L, Li CQ, Trudel LJ, Yasui H, Vallet S, Kutok JL, Chauhan D, Mitsiades CS, Saavedra JE, Wogan GE, Keefer LK, Shami PJ, and Anderson KC. JS -K, a GST-Activated Nitric Oxide Generator, Induces DNA Double Strand Breaks, activates DNA Damage Response Pathways, and Induces Apoptosis, in vitro and in vivo in Human Multiple Myeloma Cells. Blood, 110(2):709-18, 2007.

Sengupta S, Eavarone D, Capila I, Zhao G, Watson N, Kiziltepe T, Sasisekharan R. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature, 436(7050):568-72, 2005.

Hideshima T, Chauhan D, Kiziltepe T, Ikeda H, Okawa Y, Podar K, Raje N, Protopopov A, Munshi NC, Richardson PG, Carrasco RD, Anderson KC. Biologic sequelae of IκB kinase (IKK) inhibition in multiple myeloma: therapeutic implications.. Blood, 113 (21):5228-36, 2009.

Summary of Activities/Interests

Pre-clinical drug validation in cancers
Nanoparticle based drug delivery
Biochemical stabilization of biomolecular therapeutics

News

Nanoparticles Engineered at Notre Dame Promise to Improve Blood Cancer Treatment

June 29, 2012

Researchers from the University of Notre Dame have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.

Nanoparticles Engineered at Notre Dame Promise to Improve Blood Cancer Treatment

June 19, 2012

Researchers from the University of Notre Dame have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.

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