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Basar Bilgicer

Basar Bilgicer

Email: bbilgicer@nd.edu

Phone: 574-631-1429

Office: 205C McCourtney Hall

Education

B.S. Chemistry, Bogazici University, Turkey (1998)

Ph.D. Chemistry, Tufts University, MA (2005)

Biography

Postdoctoral Fellow, Chemistry, Harvard University, MA (2005-2008)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, IN (2008-present)
Assistant Professor, Department of Chemistry and Biochemistry, University of Notre Dame, IN (2008-present)

Publications

Tanyel Kiziltepe, Jonathan D. Ashley, Jared M. Stefanick, Yu Meng Qi, Nathan J. Alves, Michael W. Handlogten, Rudolph Navari, and Basar Bilgicer. "VLA4 Targeting Multifunctional Nanoparticles Overcome Drug Resistance and Inhibit Tumor Growth in Multiple Myeloma". Blood Cancer Journal 2012, 2, e64; doi:10.1038/bcj.2012.10.

Nathan J. Alves, Tanyel Kiziltepe, and Basar Bilgicer. "Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection". Langmuir 2012, doi: 10.1021/la301887s.

Michael W. Handlogten, Tanyel Kiziltepe, Nathan J. Alves and Basar Bilgicer. "Homotetravalent Synthetic Allergen Design Reveals The Significance of Moderate Affinity Epitopes in Mast Cell Degranulation". ACS Chemical Biology 2012, doi: 10.1021/cb300193f.

Nathan J. Alves, Samuel D. Stimple, Michael W. Handlogten, Tanyel Kiziltepe and Basar Bilgicer. "A Small Molecule Based Affinity Chromatography Method for Antibody Purification via Nucleotide Binding Site Targeting". Analytical Chemistry 2012, doi: 10.1021/ac300952r.

Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. "A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes". ACS Nano 2013; 7 (4); 2935–2947.

Haihua Xiao, Jared Stefanick, Xiaoyu Jia, Xiabin Jing, Tanyel Kiziltepe, Yu Zhang, and Basar Bilgicer. "Micellar Nanoparticle Formation via Electrostatic Interactions for Delivering Multinuclear Platinum (II) Drugs". ChemComm 2013; doi:10.1039/C3CC39119A.

Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shaw, Rudolph M. Navari, Tanyel Kiziltepe and Basar Bilgicer. "Selective Photocrosslinking of Functional Ligands to Antibodies via the Conserved Nucleotide Binding Site". Biomaterials 2013, doi: 10.1016/j.biomaterials.2013.03.082.

Jared Stefanick, Jonathan Ashley, and Basar Bilgicer. "Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles Through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length". ACS Nano 2013; 7 (9); 8115–8127.

Michael W. Handlogten, Tanyel Kiziltepe, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. "Selective Inhibition of Weak-Affinity Epitope-IgE Interactions via Heterobivalent Inhibitor Design Prevents Mast Cell Degranulation". Nature Chemical Biology 2013, doi: 10.1038/nchembio.1358.

Summary of Activities/Interests

Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).

Basar Bilgicer is fighting to cure food allergies. To support this important research, visit SupportingNotreDame.

 

News

Researchers develop first functional targeted inhibitors of peanut allergens

April 10, 2019

In a new study published in the Proceedings of the National Academy of Sciences, researchers at the University of Notre Dame have effectively prevented the binding of peanut allergens with immunoglobulin E to suppress the allergic reaction to peanuts using a first-in-class design of allergen-specific inhibitors.

Researchers develop first functional targeted inhibitors of peanut allergens

April 10, 2019

In a new study published in the Proceedings of the National Academy of Sciences, researchers at the University of Notre Dame have effectively prevented the binding of peanut allergens with immunoglobulin E to suppress the allergic reaction to peanuts using a first-in-class design of allergen-specific inhibitors.

Allergic to the cure: Researchers create a new and quicker way to detect platin drug allergies for cancer patients

March 15, 2019

Platins, the most widely used chemotherapeutic drugs, are displaying an alarming rise in drug hypersensitivity reactions much more severe than the watery eyes or runny noses associated with hay fever, which is also a Type 1, immediate hypersensitivity reaction. A Notre Dame-led team has developed a safer way of determining hypersensitivity in patients.

Allergic to the cure: Researchers create a new and quicker way to detect platin drug allergies for cancer patients

March 15, 2019

Platins, the most widely used chemotherapeutic drugs, are displaying an alarming rise in drug hypersensitivity reactions much more severe than the watery eyes or runny noses associated with hay fever, which is also a Type 1, immediate hypersensitivity reaction. A Notre Dame-led team has developed a safer way of determining hypersensitivity in patients.

Novel Platform Uses Nanoparticles to Detect Peanut Allergies

June 27, 2017

Researchers in Notre Dame's Department of Chemical Engineering have developed a novel platform to more accurately detect and identify the presence and severity of peanut allergies, without directly exposing patients to the allergen.