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Hsueh-Chia Chang

Hsueh-Chia Chang


Phone: 574-631-5697

Office: 118B Cushing Hall


Ph.D, Princeton University, 1980

M.S., Princeton University, 1977

B.S., California Institute of Technology, 1976


Director, Center for Microfluidics and Medical Diagnostics (2003-Present)

Bayer Professor, University of Notre Dame (1998-Present)

Senior Visitor, DAMTP, Cambridge University (1993)

Chair, Chemical Engineering, University of Notre Dame (1989-1995)

Professor, University of Notre Dame (1987-1998)

Associate Professor, University of Houston (1984-1987)

Associate Professor, University of California, Santa Barbara (1983-84)

Assistant Professor, University of California, Santa Barbara (1980-1983)

Prof Chia Chang, the Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics, is a leading researcher in micro/nanofluidics, particularly in the area of nano-electrokinetics. He has just published a Cambridge Univ Press book on the subject. His group combines analysis and physical insight to discover new physical phenomena and to develop patented devices for technology transfer. More than 20 of his former PhD students are now teaching in leading academic universities throughout the world. Prof Chang is the founding Editor of Biomicrofluidics, an American Institute of Physics journal. He has received many awards including the Frankiel Award from the American Physical Society and the Presidential Young Investigator Award from NSF. A fellow of APS, he has delivered more than 20 keynote/plenary lectures and has more than 200 publications with over 3000 citations.

Professional Activities

Director, Center for Microfluidics and Medical Diagnostics to initiate tech transfer activities at Notre Dame (2003-Present)

Founder, Advances in Microfluidics and Nanofluidcs AMN Conference at Hong Kong, Singapore, Dalian and Notre Dame (2009-2013)

Inaugural Steering Committee, Advanced Diagnostics and Therapeutics Initiative Notre Dame (2009)

Author of “Electrokinetically Driven Microfluidics and Nanofluidics”, Cambridge Uni Press (2009)

Chief and founding Editor: Biomicrofludics 2006 (2011 Impact Factor: 3.895)

Author of “Complex Wave Dynamics on Falling Films”, Elsevier Press (2002)

Chief Scientific Advisor, FCubed LLC, with 10 employees


Sun, G., Slouka, Z. and Chang, H.-C., “Fluidic Based Ion Memristors and Ion Latches”, Small,11, 5206-5213(2015).

Taller, D., Richards, K., Slouka, Z., Senapati, S., Hill, R., Go, D. B., & Chang, H. C. "On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis " (Cover article), Lab on Chip, 15, 1656(2015)

Slouka, Z., Senapati, S. and Chang, H.-C., “Microfluidic Systems with Ion-Selective Membranes”, Annual Review of Analytical Chemistry, 7, 317-335 (2014).

 Chang, H.-C., Yossifon, G. and Demekhin, E. A. , “Nanoscale Electrokinetics and Microvortices: How Microhydrodynamics Affects Nanofluidic Ion Flux”, Annual Rev of Fluid Mech, 44, 401-426 (2012).

Maheshwari, S. and Chang, H.-C., "Assembly of multi-stranded nanofiber threads through AC electrospinning", Advanced Materials, 21, 349 (2009).

 Basuray, S. , Senapati,  S.,  Ajian, A. , Mahon, A. R. and Chang, H.-C., “Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive and Mismatch-Discriminating DNA Hybridization”, ACS Nano, 3, 1823 (2009).

Chetwani, N., Maheshwari, S. and Chang, H.-C., “Universal Cone Angle of ac Electrosprays due to net charge entrainment”, Phys Rev Lett., 101, 204501 (2008).


1st Source Commercialization Award, Notre Dame (2013)

United Kingdom Royal Society of Engineering Distinguished Professorship (2011)

Corrsin Hydrodynamics Lecture, Johns Hopkins (2002)

Fellow, American Physical Society (1997)

Pattern Lectureship, University of Colorado (1992)

Francois N. Frenkiel Award, American Physical Society (1991)

Sigma Chi Faculty Research Award, University of Notre Dame (1990)

Colburn Lectureship, University of Delaware (1988)

Presidential Young Investigator, National Science Foundation (1985)

Regent's Junior Faculty Award, University of California, Santa Barbara (1980)

Summary of Activities/Interests

We explore and apply electrokinetic phenomena to develop new diagnostic and micro/nanofluidic devices that are portable, sensitive and fast. We are particularly interested in designing new molecular sensing and analysis technologies based on AC and non-equilibrium electrokinetics at the surface of nanoporous membranes and nanostructure assemblies. Devices and techniques under development include DNA/RNA sensing, on-chip pH actuation, Carbon Nanotube/Nanocolloid molecular sensors, nanofuidic diodes, plasmonic sensors etc. Three technologies have been licensed to FCubed LLC of Notre Dame Innovation Park and we are integrating them into diagnostic devices for environmental, medical and food safety applications.


Notre Dame announces awardees of the Science of Wellness Catalyst Seed Grant program

January 16, 2019

Sixteen faculty members from the University of Notre Dame have been awarded funding from the University’s Science of Wellness Initiative’s Catalyst Seed Grant program.

Will heart cells help solve our most complex problems?

August 21, 2018

As part of a new study, researchers at the University of Notre Dame aim to create a more optimal computer network for solving complex problems — using heart cells.

Nine Faculty Members Awarded Inaugural Mexico City Collaboration Grants

August 2, 2017

Notre Dame International has awarded nine faculty members inaugural Mexico City Collaboration Grants in support of the University's broader strategy to engage Mexico and Latin America by building upon existing partnerships and creating new opportunities for research, scholarship and graduate training.

Blue-sky Biomedical Projects Launched by New Funding

August 30, 2016

Advanced Diagnostics & Therapeutics (AD&T), a strategic research initiative at the University of Notre Dame, has announced the recipients of its Discovery Fund awards for 2016. Innovative research includes efforts to treat Parkinson’s disease, understand heart disease and strokes, tackle bacterial drug resistance.

Agreement between Engineering, Universidad de Chile Encourages Academic Exchange

June 29, 2016

The Department of Chemical and Biomolecular Engineering (CBE) at the University of Notre Dame has entered into a five-year agreement with the Department of Chemical Engineering and Biotechnology (DIQBT) of the College of Physical and Mathematical Sciences at the Universidad de Chile in Santiago, Chile, that encourages academic exchange and collaborative initiatives at both the undergraduate and graduate levels.