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Hsueh-Chia Chang

Hsueh-Chia Chang

Email: hchang@nd.edu

Phone: 574-631-5697

Office: 118B Cushing Hall

Education

Ph.D, Princeton University, 1980

M.S., Princeton University, 1977

B.S., California Institute of Technology, 1976

Biography

Director, Center for Microfluidics and Medical Diagnostics (2003-Present)

Bayer Professor, University of Notre Dame (1998-Present)

Senior Visitor, DAMTP, Cambridge University (1993)

Chair, Chemical Engineering, University of Notre Dame (1989-1995)

Professor, University of Notre Dame (1987-1998)

Associate Professor, University of Houston (1984-1987)

Associate Professor, University of California, Santa Barbara (1983-84)

Assistant Professor, University of California, Santa Barbara (1980-1983)

Prof Chia Chang, the Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics, is a leading researcher in micro/nanofluidics, particularly in the area of nano-electrokinetics. He has just published a Cambridge Univ Press book on the subject. His group combines analysis and physical insight to discover new physical phenomena and to develop patented devices for technology transfer. More than 20 of his former PhD students are now teaching in leading academic universities throughout the world. Prof Chang is the founding Editor of Biomicrofluidics, an American Institute of Physics journal. He has received many awards including the Frankiel Award from the American Physical Society and the Presidential Young Investigator Award from NSF. A fellow of APS, he has delivered more than 20 keynote/plenary lectures and has more than 200 publications with over 3000 citations.

Professional Activities

Director, Center for Microfluidics and Medical Diagnostics to initiate tech transfer activities at Notre Dame (2003-Present)

Founder, Advances in Microfluidics and Nanofluidcs AMN Conference at Hong Kong, Singapore, Dalian and Notre Dame (2009-2013)

Inaugural Steering Committee, Advanced Diagnostics and Therapeutics Initiative Notre Dame (2009)

Author of “Electrokinetically Driven Microfluidics and Nanofluidics”, Cambridge Uni Press (2009)

Chief and founding Editor: Biomicrofludics 2006 (2011 Impact Factor: 3.895)

Author of “Complex Wave Dynamics on Falling Films”, Elsevier Press (2002)

Chief Scientific Advisor, FCubed LLC, with 10 employees http://fcubed.iviehost.com/

Publications

Sun, G., Slouka, Z. and Chang, H.-C., “Fluidic Based Ion Memristors and Ion Latches”, Small,11, 5206-5213(2015).

Taller, D., Richards, K., Slouka, Z., Senapati, S., Hill, R., Go, D. B., & Chang, H. C. "On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis " (Cover article), Lab on Chip, 15, 1656(2015)

Slouka, Z., Senapati, S. and Chang, H.-C., “Microfluidic Systems with Ion-Selective Membranes”, Annual Review of Analytical Chemistry, 7, 317-335 (2014).

 Chang, H.-C., Yossifon, G. and Demekhin, E. A. , “Nanoscale Electrokinetics and Microvortices: How Microhydrodynamics Affects Nanofluidic Ion Flux”, Annual Rev of Fluid Mech, 44, 401-426 (2012).

Maheshwari, S. and Chang, H.-C., "Assembly of multi-stranded nanofiber threads through AC electrospinning", Advanced Materials, 21, 349 (2009).

 Basuray, S. , Senapati,  S.,  Ajian, A. , Mahon, A. R. and Chang, H.-C., “Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive and Mismatch-Discriminating DNA Hybridization”, ACS Nano, 3, 1823 (2009).

Chetwani, N., Maheshwari, S. and Chang, H.-C., “Universal Cone Angle of ac Electrosprays due to net charge entrainment”, Phys Rev Lett., 101, 204501 (2008).

Awards

1st Source Commercialization Award, Notre Dame (2013)

United Kingdom Royal Society of Engineering Distinguished Professorship (2011)

Corrsin Hydrodynamics Lecture, Johns Hopkins (2002)

Fellow, American Physical Society (1997)

Pattern Lectureship, University of Colorado (1992)

Francois N. Frenkiel Award, American Physical Society (1991)

Sigma Chi Faculty Research Award, University of Notre Dame (1990)

Colburn Lectureship, University of Delaware (1988)

Presidential Young Investigator, National Science Foundation (1985)

Regent's Junior Faculty Award, University of California, Santa Barbara (1980)

Summary of Activities/Interests

We explore and apply electrokinetic phenomena to develop new diagnostic and micro/nanofluidic devices that are portable, sensitive and fast. We are particularly interested in designing new molecular sensing and analysis technologies based on AC and non-equilibrium electrokinetics at the surface of nanoporous membranes and nanostructure assemblies. Devices and techniques under development include DNA/RNA sensing, on-chip pH actuation, Carbon Nanotube/Nanocolloid molecular sensors, nanofuidic diodes, plasmonic sensors etc. Three technologies have been licensed to FCubed LLC of Notre Dame Innovation Park and we are integrating them into diagnostic devices for environmental, medical and food safety applications.

News

Cutting the time on early disease diagnoses with extracellular vesicles

May 20, 2019

A research team led by the University of Notre Dame is working to cut the test time for disease biomarkers. The new timeline — 30 minutes instead of 13 hours — uses even smaller sample sizes to offer a new liquid biopsy option.

Cutting the time on early disease diagnoses with extracellular vesicles

May 20, 2019

A research team led by the University of Notre Dame is working to cut the test time for disease biomarkers. The new timeline — 30 minutes instead of 13 hours — uses even smaller sample sizes to offer a new liquid biopsy option.

Chang to receive AES Lifetime Achievement Award

March 11, 2019

Hsueh-Chia Chang, the Bayer Professor of Chemical and Biomolecular Engineering at the University of Notre Dame, has been selected to receive the AES Lifetime Achievement Award.

Chang to receive AES Lifetime Achievement Award

March 11, 2019

Hsueh-Chia Chang, the Bayer Professor of Chemical and Biomolecular Engineering at the University of Notre Dame, has been selected to receive the AES Lifetime Achievement Award.

More than a decade as a chief editor, always a pioneer

January 24, 2019

In December 2018, after 12 years of leadership, Hsueh-Chia Chang, the Bayer Professor of Chemical and Biomolecular Engineering at the University of Notre Dame, stepped down as the founding and chief editor of Biomicrofluidics.