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Jeremiah Zartman

Jeremiah J Zartman

Email: jzartman@nd.edu

Phone: 574-631-0455

Office: 205D McCourtney Hall


Ph.D., Chemical Engineering, Princeton University, 2009

M.A., Chemical Engineering, Princeton University, 2006

B.S., Chemical Engineering and Engineering Physics, University of Colorado at Boulder, 2004


Research Assistant, Dep. of Mech. Eng. and Membrane Applied Science & Technology Center, Univ. of Colorado, Boulder, CO (1999-2002)
REU participant, University of Colorado-Boulder,  Boulder, CO (2000)
REU Research Assistant, M.I.T., Cambridge, MA (2002)
Research Assistant, University of Colorado, Boulder, CO (2004)
Postdoctoral Research Scientist, University of Zurich, Switzerland (2009-2011)
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN (2012-2018)
Associate Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN (2018-present)

Professional Activities

Member, American Institute of Chemical Engineers
Member, Genetics Society of America
Affiliated with Advanced Diagnostics and Therapeutics (AD&T) at the University of Notre Dame
Affiliated with the Mike and Josie Harper Cancer Research Institute (University of Notre Dame/Indiana School of Medicine South Bend)


Breuer, E.-K., Rao, V., Fukushiro-Lopes, D., Dalheim, A., Burnette, M., Zartman, J., Kaja, S, Wells, C., Campo, L., Curtis, K.J., Romero-Moreno, R., Littlepage, L.E., Niebur, G.L., Nishimura, M.I., Gentile, S. “Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.” Cell Death & Disease, 10, no. 3 (2019): 180. doi:10.1038/s41419-019-1429-0.

Brodskiy, P. A., Q. Wu, D. K. Soundarrajan, F. J. Huizar, J. Chen, P. Liang, Narciso, C., Levis, M.K., Arredondo-Walsh, N., Chen, D.Z., Zartman, J.J.  “Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.” Biophysical Journal, 116, no. 4, 19 February 2019: 725-740. https://doi.org/10.1016/j.bpj.2019.01.007.

Brodskiy, Pavel A., Qinfeng Wu, Nilay Kumar Kumar, Vijay Kumar Naidu Velagala, Kara L. Snyder, Francisco J. Huizar, Seth J. Tautges, Meaghan Snyder, and Jeremiah J. Zartman. “Mapping the calcium signalsome during Drosophila wing development.” IFAC-PapersOnLine 51, no. 19 (2018): 108-109.

Kumar, Nilay, Pavel Brodsky, and Jeremiah Zartman. “Single cell analysis of oscillatory Ca2+ signalling in epithelial cells.” IFAC-PapersOnLine 51, no. 19 (2018): 116-117.

Paravitorghabeh, Ramezan , and Jeremiah J. Zartman. “Modeling intercellular calcium dynamics in an epithelial organ using Dynamic Mode Decomposition.” IFAC-PapersOnLine 51, no. 19 (2018): 120-123.

Zhang, Siyuan, Jeremiah Zartman, David Hoelzle, and Cody Narciso. “Microfluidic devices, systems, and methods for evaluating tissue samples.” U.S. Patent 9,975,121, issued May 22, 2018.

Liang, Peixian, Jianxu Chen, Pavel A. Brodskiy, Qinfeng Wu, Yejia Zhang, Yizhe Zhang, Lin Yang, Jeremiah J. Zartman, and Danny Z. Chen. “A new registration approach for dynamic analysis of calcium signals in organs.” In Biomedical Imaging (ISBI 2018), 2018 IEEE 15th International Symposium on, pp. 934-937. IEEE, 2018. Available on Arxiv.

Brodskiy, P. and Zartman, J.J.The embedded consultant: calcium as a signal integrator in developing epithelial tissues.” 2018 Phys. Biol. 15 0510012018 doi: 10.1088/1478-3975/aabb18.

Narciso C., Zartman J.J.* “Reverse engineering organogenesis through feedback loops between model systems.” Current opinion in biotechnology, 2017, 52, 1-8. doi: 10.1016/j.copbio.2017.12.009.

Fukushiro-Lopes, D.F., Hegel, A.D., Rao, V., Wyatt, D., Baker, A.T., Breuer, E.K., Osipo, C., Zartman, J.J., Burnette, M., Kaja, S., Kouzoukas, D., Burris, S., Jones, W.K., Gentile, S. “Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.” Oncotarget 2017, 9(3): 3321-3337. doi: 10.18632/oncotarget.22925.

Narciso, C. E., Contento, N. M., Storey, T. J., Hoelzle, D. J., and Zartman, J. J.* “Release of applied mechanical loading stimulates intercellular calcium waves in Drosophila wing discs” Biophysical Journal 113: 2, 491-501 (2017). doi: 10.1016/j.bpj.2017.05.051.

Höök, P., Brito-Robinson, T., Narciso, C., Kim, O., Goodson, R.I., Weisel, J.W.*, Alber, M.S.*, and Zartman, J.J.*. “Whole blood clot optical clearing for nondestructive 3D imaging and quantitative analysis”. Biomedical Optics Express 8 (8), 3671-3686.

Nematbakhsh, A., Sun, W., Brodskiy, P. A., Amiri, A., Narciso, C., Xu, Z., Zartman, J. J.*, and Alber, M. S.* “Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.” PLOS Computational Biology 2017;13:e1005533.

Restrepo, S., Zartman, J.J., and Basler, K. “Cultivation and Live Imaging of Drosophila Imaginal Discs” Methods in Molecular Biology (Clifton, N.J.) 1478, (2016): 203–213. doi:10.1007/978-1-4939-6371-3_11.

Kursawe, J., Bardenet, R., Zartman, J. J., Baker, R. E., and Fletcher, A. G. “Robust Cell Tracking in Epithelial Tissues through Identification of Maximum Common Subgraphs” Journal of The Royal Society Interface 13, no. 124 (2016): 20160725. doi:10.1098/rsif.2016.0725. 

Narciso C, Cowdrick KR, Zellmer V, Brito-Robinson T, Brodskiy P, Hoelzle DJ, Zhang S, Zartman JJ. On-chip three-dimensional tissue histology for microbiopsies. Biomicrofluidics. 2016 Mar 10 (2): 021101.

Kursawe J, Brodskiy PA, Zartman JJ, Baker RE, Fletcher AG. Capabilities and Limitations of Tissue Size Control Through Passive Mechanical Forces. PLOS Comput Biol 11, no. 12 (2015): e1004679. doi:10.1371/journal.pcbi.1004679

Burnette M, Zartman JJ. (2015) Spatiotemporal patterning of polyamines in Drosophila development. Amino acids, 1-6. DOI: 10.1007/s00726-015-2093-z

Narciso C, Wu Q, Brodskiy P, Garston G, Baker R, Fletcher A, Zartman J. Patterning of wound-induced intercellular Ca2+ flashes in a developing epithelium. Phys Biol. 2015 Oct 1;12(5):056005. DOI: http://dx.doi.org/10.1088/1478-3975/12/5/056005.

Burnette M., Brito-Robinson T., Li J., Zartman J. An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines. Mol BioSyst (2014), DOI: 10.1039/C4MB00155A. 

Buchmann A, Alber M, Zartman JJ, Sizing it up: The mechanical feedback hypothesis of organ growth regulation, Seminars in Cell and Developmental Biology (2014), http://dx.doi.org/10.1016/j.semcdb.2014.06.018. 

Restrepo, S*, Zartman, JJ*, Basler, K. Coordination of Patterning and Growth by the Morphogen DPP. Curr. Biol. 24, R245–R255 (2014).

Zartman J*, Restrepo S*, Basler K. (2013) A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development. Feb;140(3):667–674. 

Zartman JJ*, Cheung LS*, Niepielko MG, Bonini C, Haley B, Yakoby N, Shvartsman SY (2011). Pattern formation by a moving morphogen source. Phys Biol. Aug;8(4):045003. 2012 

Zartman JJ and Shvartsman SY (2010). Unit Operations of Tissue Development: Epithelial Folding. Annual Review of Chemical and Biomolecular Engineering 1:231-46.

Zartman JJ, Kanodia JS, Cheung LS, Shvartsman SY (2009) Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis. Development 136(17):2903-2911. 

Yan S-J, Zartman JJ, Zhang M, Scott A, Shvartsman SY, Li WX. (2009) Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Molecular Systems Biology 5:278. 

Zartman JJ, Kanodia JS, Yakoby N, Schafer X, Watson C, Schlichting K, Dahmann C, Shvartsman SY (2009) Expression patterns of cadherin genes in Drosophila oogenesis. Gene Expr Patterns 9(1):31-36. 

Yakoby N, Bristow CA, Gong D, Schafer X, Lembong J, Zartman JJ, Halfon MS, Schupbach T, Shvartsman SY (2008) A Combinatorial Code for Pattern Formation in Drosophila Oogenesis. Dev Cell 15(5):725-737.  

Zartman JJ, Yakoby N, Bristow CA, Zhou X, Schlichting K, Dahmann C and Shvartsman, SY (2008) Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis. Developmental Biology 322:289-301. 

Zartman JJ, and Shvartsman SY (2007) Enhancer organization: transistor with a twist or something in a different vein? Curr Biol 17(24):R1048-1050. 

Pekny M, Zartman J, Krantz W, Greenberg A, Todd, P. (2003) Flow-visualization during macrovoid pore formation in dry-cast cellulose acetate membranes. J Memb Sci 211:71-90. 

Khare V, Greenberg A, Zartman J, Krantz W, Todd P (2002) Macrovoid growth during polymer membrane casting. Desalination 145:17-23.

Pekny MR, Zartman J, Greenberg AR, Krantz, WB, Todd P (2002) Macrovoid pore formation in dry-east cellulose acetate membranes: buoyancy studies. J Memb Sci 205:11-21. 

Narciso C., Zartman J.J. “Reverse engineering organogenesis through feedback loops between model systems.” Current opinion in biotechnology201752, 1-8. doi: 10.1016/j.copbio.2017.12.009  

Brodskiy, P. and Zartman, J.J. “The embedded consultant: calcium as a signal integrator in developing epithelial tissues.” 2018 Phys. Biol. 15 0510012018 doi: 10.1088/1478-3975/aabb18.    

Fukushiro-Lopes, D.F., Hegel, A.D., Rao, V., Wyatt, D., Baker, A.T., Breuer, E.K., Osipo, C., Zartman, J.J., Burnette, M.@, Kaja, S., Kouzoukas, D., Burris, S., Jones, W.K., Gentile, S. “Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.” Oncotarget 2017, 9(3): 3321-3337.

Book Chapters

Zartman, J.J. “Chapter 7 - Organ Culture Methods for the Drosophila Wing Imaginal Disc.” In Drosophila Cells in Culture (Second Edition) (ed. Echalier, G., Perrimon, N., and Mohr, S. E.), 2017, pp. 145–164. Academic Press. ISBN: 9780128094730. doi.org/10.1016/B978-0-12-809473-0.00007-5


2016 CAREER award

2018 Notre Dame Integrated Imaging Facility Award for Best Biological Imaging Publication 

2018 Biomedical Engineering Society “Rising Star Award” 

Long-term EMBO postdoctoral fellowship (2010-2011)
Received February 1, 2010

Schering-Plough Science and Innovation Award
Received March 3, 2008

Princeton Hertz Fellowship (2004-2009)
Received September 1, 2004

Summary of Activities/Interests

Developing new strategies for building tissues and treating degenerative tissue diseases requires investigating animal development from an engineering perspective. Probing animal development with quantitative tools can potentially improve traditional methods of tissue engineering as well as inspire completely novel methods for creating synthetic organs. In the Zartman lab, we are focused on the systematic analysis of chemical and mechanical signaling at the tissue scale, including developing computational models of how cells self-organize into organs of the correct shape and size. We address these questions using experiments and modeling in systems such as Drosophila that are amenable to sophisticated genetic approaches, live imaging and in vitro culture. The main objective of the lab is to synthesize mechanistic models of two fundamental processes during development: 1. the control of organ growth, and 2. the organization of cellular sheets into three-dimensional structures.

Chemical and biological engineers can contribute significantly toward understanding how organ size and shape are regulated by utilizing a diverse toolkit of skills: solving reaction-diffusion and transport problems, utilizing control and decision theory toward the reverse engineering of transcriptional networks, applying quantitative and statistical methods in the optimization of next-generation growth media for organ development in vitro, and employing experimental knowledge in the analysis of soft materials.


Zartman named member of Michiana Forty under 40 Class of 2019

April 23, 2019

Jeremiah J. Zartman, associate professor of chemical and biomolecular engineering at the University of Notre Dame, has been named a member of the Michiana Forty Under 40 Class of 2019 by the South Bend Regional Chamber.

Zartman named member of Michiana Forty under 40 Class of 2019

April 23, 2019

Jeremiah J. Zartman, associate professor of chemical and biomolecular engineering at the University of Notre Dame, has been named a member of the Michiana Forty Under 40 Class of 2019 by the South Bend Regional Chamber.

Notre Dame researchers to tackle autism, preeclampsia and more through new funding

September 7, 2018

Nine faculty from the University of Notre Dame have received awards for five projects from the Advanced Diagnostics and Therapeutics’ Discovery Fund. Each year, grants from the Discovery Fund are awarded to researchers who propose novel technologies and diagnostics that can improve human and environmental health.

Blue-sky Biomedical Projects Launched by New Funding

August 30, 2016

Advanced Diagnostics & Therapeutics (AD&T), a strategic research initiative at the University of Notre Dame, has announced the recipients of its Discovery Fund awards for 2016. Innovative research includes efforts to treat Parkinson’s disease, understand heart disease and strokes, tackle bacterial drug resistance.