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Ryan Roeder

Ryan K. Roeder

Email: rroeder@nd.edu

Phone: 574-631-7003

Office: 148 Multidisciplinary Building

Education

B.S., Materials Engineering - Purdue University, 1994

Ph.D. Materials Engineering - Purdue University, 1999

Biography

Dr. Roeder's research interests broadly span biomaterials, including nanoparticles for targeted contrast agents and drug delivery, and scaffolds for repairing and regenerating tissues, as well biomechanics, including the mechanobiology and micromechanics of musculoskeletal tissues.  Dr. Roeder's research has been supported by the National Science Foundation (NSF), the National Institutes of Health (NIH), the U.S. Army Medical Research and Materiel Command (USAMRMC), the Congressionally-Directed Medical Research Programs (CDMRP), the Defense Advanced Research Projects Agency (DARPA), as well as a number of private foundations and corporations.  Dr. Roeder’s research group is multidisciplinary, including students with backgrounds in biomedical engineering, materials engineering, mechanical engineering, chemical engineering, and chemistry.  Ph.D. graduates have been placed in postdoctoral positions, research hospitals, biomedical industry positions, and faculty positions.  Dr. Roeder's research has led to the formation of HAPPE Spine LLC which is commercializing porous and bioactive interbody spinal fusion cages composed hydroxyapatite whisker reinforced polyetheretherketone.

Selected Recent Publications

M.D. Hunckler, E.D. Chu, A.P. Baumann, T.E. Curtis, M.J. Ravosa, M.R. Allen and R.K. Roeder, “The fracture toughness of small animal cortical bone measured using arc-shaped tension specimens: Effects of bisphosphonate and deproteinization treatments,” Bone, 105, 67-74 (2017). doi:10.1016/j.bone.2017.08.015

T.E. Curtis and R.K. Roeder, “Effects of calibration methods on quantitative material decomposition in photon-counting spectral computed tomography using a maximum a posterioriestimator,” Med. Phys., 44[10] 5187-5197 (2017). doi:10.1002/mp.12457

R.K. Roeder, T.E. Curtis, P.D. Nallathamby, L.E. Irimata, T.L. McGinnity, L.E. Cole, T. Vargo-Gogola and K.D. Cowden Dahl, “Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography and Application to Cancer Imaging,” Proc. SPIE, 10132, 101320X (2017). doi:10.1117/12.2255688

M.J. Meagher, R.J. Kane and R.K. Roeder, “Tissue Scaffolds Having Bone Growth Factors,” U.S. Patent No. 9,550,012, January 24, 2017.

M. Garcia-Leiner, M.T.F. Reitman, M.J. El-Hibri and R.K. Roeder, “Structure-Property Relationships in Commercial Polyetheretherketone (PEEK) Resins,” Polym. Eng. Sci., 57 [9] 955-964 (2017). doi:10.1002/pen.24472

P.D. Nallathamby, J. Hopf, L.E. Irimata, T.L. McGinnity and R.K. Roeder, “Preparation of fluorescent Au-SiO2 core-shell nanoparticles and nanorods with tunable silica shell thickness and surface modification for immunotargeting,” J. Mater. Chem. B, 4, 5418-5428 (2016). doi:10.1039/c6tb01659f

T.L. McGinnity, O. Dominguez, T.E. Curtis, P.D. Nallathamby, A.J. Hoffman and R.K. Roeder, “Hafnia (HfO2) nanoparticles as an X-ray contrast agent and mid-infrared biosensor,” Nanoscale, 8, 13627-13637 (2016). doi:10.1039/c6nr03217f

M.J. Meagher, H.E. Weiss-Bilka, M.E. Best, D.R. Wagner and R.K. Roeder, “Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction,” J. Biomed. Mater. Res., 104A, 2178-2188 (2016). doi:10.1002/jbm.a.35760

L.C. Cole, T. Vargo-Gogola and R.K. Roeder, “Targeted delivery to bone and mineral deposits using bisphosphonate ligands,” Adv. Drug Deliv. Rev., 99, 12-27 (2016). doi:10.1016/j.addr.2015.10.005

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of microcalcifications in radiographically dense mammary tissue using targeted gold nanoparticles,” ACS Nano, 9 [9] 8923-8932 (2015). doi:10.1021/acsnano.5b02749  Press release.

A.P. Baumann, M.W. Aref, T.L. Turnbull, A.G. Robling, G.L. Niebur, M.R. Allen and R.K. Roeder, “Development of an In Vivo Rabbit Ulnar Loading Model,” Bone, 75, 55-61 (2015). 10.1016/j.bone.2015.01.022

R.J. Kane, H.E. Weiss-Bilka, M.J. Meagher, Y. Liu, J.A. Gargac, G.L. Niebur, D.R. Wagner and R.K. Roeder, “Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties,” Acta Biomaterialia, 17, 16-25 (2015). doi:10.1016/j.actbio.2015.01.031

L.E. Cole, R.D. Ross, J.M.R. Tilley, T. Vargo-Gogola and R.K. Roeder, “Gold nanoparticles as contrast agents in X-ray imaging and computed tomography,” Nanomedicine, 10 [2] 321-341 (2015). doi:10.2217/nnm.14.171

Summary of Activities/Interests

Biomaterials, Biomechanics, Materials Science, Mechanical Behavior, Nanoparticles, Scaffolds

News

NDnano announces 2018 Seed Grant Program Recipients

July 18, 2018

Nine faculty members from the University of Notre Dame’s College of Engineering and College of Science have been awarded four grants through the Center for Nano Science and Technology (NDnano) Seed Grant Program. 

Researchers Tackle Ovarian Cancer Using a Multidisciplinary Approach

September 11, 2017

September is National Ovarian Cancer Awareness Month. Ovarian cancer is among the most deadly of all cancers, though because of less awareness, most cities won’t be as blanketed in teal (ovarian cancer’s awareness color) as they are bathed in pink for October’s focus on breast cancer. But researchers at the Harper Cancer Research Institute, a collaboration between the University of Notre Dame and the Indiana University School of Medicine South Bend, are working with community partners to not only foster awareness of ovarian cancer but also to develop tests for early detection, create novel chemotherapies, and target a cure.

Fighting for Better Cancer Detection

October 28, 2016

A mammogram’s ability to detect tumors at early stages has made breast cancer one of the most treatable forms of cancer. Still there are almost 50,000 missed diagnoses every year. Engineering professor Ryan K. Roeder has devised a way in which gold nanoparticles can be injected into the breast and attach to indicators of cancer, so they can be clearly seen.

Researchers Use Nanotechnology to Fight Breast Cancer

October 9, 2015

October is Breast Cancer Awareness Month, an annual campaign to increase awareness of the disease and the importance of early detection. Researchers at the University of Notre Dame are conducting innovative research aimed at improvements in early detection by molecular imaging.

The Transformation of Cancer Imaging: From Shades of Gray to Living Color

September 30, 2015

Promising a transformation in biomedical imaging, a new technology called spectral [color] computed tomography is at work on the University of Notre Dame’s campus, where researchers are giving the phrase “in living color” a new meaning.