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Ryan Roeder

Ryan K. Roeder

Email: rroeder@nd.edu

Phone: 574-631-7003

Office: 148 Multidisciplinary Building


B.S., Materials Engineering - Purdue University, 1994

Ph.D. Materials Engineering - Purdue University, 1999


Dr. Roeder's research interests broadly span biomaterials, including nanoparticles for targeted contrast agents and drug delivery, and scaffolds for repairing and regenerating tissues, as well biomechanics, including the mechanobiology and micromechanics of musculoskeletal tissues.  Dr. Roeder's research has been supported by the National Science Foundation (NSF), the National Institutes of Health (NIH), the U.S. Army Medical Research and Materiel Command (USAMRMC), the Congressionally-Directed Medical Research Programs (CDMRP), the Defense Advanced Research Projects Agency (DARPA), as well as a number of private foundations and corporations.  Dr. Roeder’s research group is multidisciplinary, including students with backgrounds in biomedical engineering, materials engineering, mechanical engineering, chemical engineering, and chemistry.  Ph.D. graduates have been placed in postdoctoral positions, research hospitals, biomedical industry positions, and faculty positions.  Dr. Roeder's research has led to the formation of HAPPE Spine LLC which is commercializing porous and bioactive interbody spinal fusion cages composed hydroxyapatite whisker reinforced polyetheretherketone.

Selected Recent Publications

T.A. Finamore, T.E. Curtis, J.V. Tedesco, K. Grandfield and R.K. Roeder, “Nondestructive, Longitudinal Measurement of Collagen Scaffold Degradation Using Computed Tomography and Gold Nanoparticles,” Nanoscale11, 4345-4354 (2019). doi:10.1039/c9nr00313d

T.E. Curtis and R.K. Roeder, “Quantification of Mixed Contrast and Tissue Compositions using Photon-Counting Spectral Computed Tomography,” J. Med. Imaging,[1] 013501 (2019). doi:10.1117/1.JMI.6.1.013501

Y. Pang, J. Yang, T.E. Curtis, S. Luo, Z. Feng, D. Huang, J.O. Morales-Ferreiro, P. Sapkota, F. Lei, J. Zhang, Q. Zhang, E. Lee, Y. Huang, R. Guo, S. Ptasinska, R.K. Roeder and T. Luo, “Exfoliated Graphene Leads to Exceptional Mechanical Properties of Composite Polymer Films,” ACS Nano13 [2] 1097-1106 (2019). doi:10.1021/acsnano.8b04734

R.K. Roeder, “Bioactive Polyaryletherketone Composites”; in the PEEK Biomaterials Handbook, 2nd Edition. Edited by S.M. Kurtz. Elsevier, Inc., Amsterdam, 2019. doi:10.1016/B978-0-12-812524-3.00012-0

L.C. Cole, T.L. McGinnity, L.E. Irimata, T. Vargo-Gogola and R.K. Roeder, “Effects of Bisphosphonate Ligands and PEGylation on Targeted Delivery of Gold Nanoparticles for Contrast-Enhanced Radiographic Detection of Breast Microcalcifications,” Acta Biomaterialia82, 122-132 (2018). doi:10.1016/j.actbio.2018.10.014

M.D. Hunckler, E.D. Chu, A.P. Baumann, T.E. Curtis, M.J. Ravosa, M.R. Allen and R.K. Roeder, “The fracture toughness of small animal cortical bone measured using arc-shaped tension specimens: Effects of bisphosphonate and deproteinization treatments,” Bone, 105, 67-74 (2017). doi:10.1016/j.bone.2017.08.015

T.E. Curtis and R.K. Roeder, “Effects of calibration methods on quantitative material decomposition in photon-counting spectral computed tomography using a maximum a posterioriestimator,” Med. Phys., 44 [10] 5187-5197 (2017). doi:10.1002/mp.12457

R.K. Roeder, T.E. Curtis, P.D. Nallathamby, L.E. Irimata, T.L. McGinnity, L.E. Cole, T. Vargo-Gogola and K.D. Cowden Dahl, “Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography and Application to Cancer Imaging,” Proc. SPIE, 10132, 101320X (2017). doi:10.1117/12.2255688

M.J. Meagher, R.J. Kane and R.K. Roeder, “Tissue Scaffolds Having Bone Growth Factors,” U.S. Patent No. 9,550,012, January 24, 2017.

M. Garcia-Leiner, M.T.F. Reitman, M.J. El-Hibri and R.K. Roeder, “Structure-Property Relationships in Commercial Polyetheretherketone (PEEK) Resins,” Polym. Eng. Sci., 57 [9] 955-964 (2017). doi:10.1002/pen.24472

P.D. Nallathamby, J. Hopf, L.E. Irimata, T.L. McGinnity and R.K. Roeder, “Preparation of fluorescent Au-SiO2 core-shell nanoparticles and nanorods with tunable silica shell thickness and surface modification for immunotargeting,” J. Mater. Chem. B, 4, 5418-5428 (2016). doi:10.1039/c6tb01659f

T.L. McGinnity, O. Dominguez, T.E. Curtis, P.D. Nallathamby, A.J. Hoffman and R.K. Roeder, “Hafnia (HfO2) nanoparticles as an X-ray contrast agent and mid-infrared biosensor,” Nanoscale, 8, 13627-13637 (2016). doi:10.1039/c6nr03217f

M.J. Meagher, H.E. Weiss-Bilka, M.E. Best, D.R. Wagner and R.K. Roeder, “Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction,” J. Biomed. Mater. Res., 104A, 2178-2188 (2016). doi:10.1002/jbm.a.35760

L.C. Cole, T. Vargo-Gogola and R.K. Roeder, “Targeted delivery to bone and mineral deposits using bisphosphonate ligands,” Adv. Drug Deliv. Rev., 99, 12-27 (2016). doi:10.1016/j.addr.2015.10.005

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of microcalcifications in radiographically dense mammary tissue using targeted gold nanoparticles,” ACS Nano, 9 [9] 8923-8932 (2015). doi:10.1021/acsnano.5b02749  Press release.

A.P. Baumann, M.W. Aref, T.L. Turnbull, A.G. Robling, G.L. Niebur, M.R. Allen and R.K. Roeder, “Development of an In Vivo Rabbit Ulnar Loading Model,” Bone, 75, 55-61 (2015). 10.1016/j.bone.2015.01.022

R.J. Kane, H.E. Weiss-Bilka, M.J. Meagher, Y. Liu, J.A. Gargac, G.L. Niebur, D.R. Wagner and R.K. Roeder, “Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties,” Acta Biomaterialia, 17, 16-25 (2015). doi:10.1016/j.actbio.2015.01.031

L.E. Cole, R.D. Ross, J.M.R. Tilley, T. Vargo-Gogola and R.K. Roeder, “Gold nanoparticles as contrast agents in X-ray imaging and computed tomography,” Nanomedicine, 10 [2] 321-341 (2015). doi:10.2217/nnm.14.171

Summary of Activities/Interests

Biomaterials, Biomechanics, Materials Science, Mechanical Behavior, Photon-Counting Spectral Computed Tomography, Nanoparticles, Scaffolds


Notre Dame launches materials science and engineering doctoral degree program

July 14, 2020

Notre Dame has added a new interdisciplinary doctoral program in Materials Science and Engineering through the College of Engineering and the College of Science.

Notre Dame launches materials science and engineering doctoral degree program

July 14, 2020

Notre Dame has added a new interdisciplinary doctoral program in Materials Science and Engineering through the College of Engineering and the College of Science.

New technology could help tackle antibiotic resistance

January 29, 2020

Prakash Nallathamby, research assistant professor of aerospace and mechanical engineering, has led a published study exhibiting a novel nanoparticle-based system that mimics how phages attack and kill bacteria.

NDnano announces 2018 Seed Grant Program Recipients

July 18, 2018

Nine faculty members from the University of Notre Dame’s College of Engineering and College of Science have been awarded four grants through the Center for Nano Science and Technology (NDnano) Seed Grant Program. 

Fighting for Better Cancer Detection

October 28, 2016

A mammogram’s ability to detect tumors at early stages has made breast cancer one of the most treatable forms of cancer. Still there are almost 50,000 missed diagnoses every year. Engineering professor Ryan K. Roeder has devised a way in which gold nanoparticles can be injected into the breast and attach to indicators of cancer, so they can be clearly seen.