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Ryan Roeder

Ryan K. Roeder


Phone: 574-631-7003

Office: 148 Multidisciplinary Building


B.S., Materials Engineering - Purdue University, 1994

Ph.D. Materials Engineering - Purdue University, 1999


Dr. Roeder's research interests broadly span biomaterials, including nanoparticles for targeted contrast agents and drug delivery, and scaffolds for regenerating tissues, as well biomechanics, including the mechanobiology and micromechanics of musculoskeletal tissues.  Dr. Roeder's research has been supported by the National Science Foundation (NSF), the National Institutes of Health (NIH), the U.S. Army Medical Research and Materiel Command (USAMRMC), the Congressionally-Directed Medical Research Programs (CDMRP), the Defense Advanced Research Projects Agency (DARPA), as well as a number of private foundations and corporations.  Dr. Roeder’s research group is multidisciplinary, including students with backgrounds in biomedical engineering, materials engineering, mechanical engineering, chemical engineering, and chemistry.  Ph.D. graduates have been placed in postdoctoral positions, research hospitals, biomedical industry positions, and faculty positions.

Selected Recent Publications

R.K. Roeder, T.E. Curtis, P.D. Nallathamby, L.E. Irimata, T.L. McGinnity, L.E. Cole, T. Vargo-Gogola and K.D. Cowden Dahl, “Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography and Application to Cancer Imaging,” Proc. SPIE, 10132, 101320X (2017). doi:10.1117/12.2255688

T.E. Curtis, J.V. Tedesco and R.K. Roeder, “Calibration methods influence quantitative material decomposition in photon-counting spectral CT,” Proc. SPIE, 10132, 101323L (2017). doi:10.1117/12.2255661

M.J. Meagher, R.J. Kane and R.K. Roeder, “Tissue Scaffolds Having Bone Growth Factors,” U.S. Patent No. 9,550,012, January 24, 2017.

M. Garcia-Leiner, M.T.F. Reitman, M.J. El-Hibri and R.K. Roeder, “Structure-Property Relationships in Commercial Polyetheretherketone (PEEK) Resins,” Polym. Eng. Sci., in press. doi:10.1002/pen.24472

P.D. Nallathamby, J. Hopf, L.E. Irimata, T.L. McGinnity and R.K. Roeder, “Preparation of fluorescent Au-SiO2 core-shell nanoparticles and nanorods with tunable silica shell thickness and surface modification for immunotargeting,” J. Mater. Chem. B, 4, 5418-5428 (2016). doi:10.1039/c6tb01659f

T.L. McGinnity, O. Dominguez, T.E. Curtis, P.D. Nallathamby, A.J. Hoffman and R.K. Roeder, “Hafnia (HfO2) nanoparticles as an X-ray contrast agent and mid-infrared biosensor,” Nanoscale, 8, 13627-13637 (2016). doi:10.1039/c6nr03217f

M.J. Meagher, H.E. Weiss-Bilka, M.E. Best, D.R. Wagner and R.K. Roeder, “Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction,” J. Biomed. Mater. Res., 104A, 2178-2188 (2016). doi:10.1002/jbm.a.35760

L.C. Cole, T. Vargo-Gogola and R.K. Roeder, “Targeted delivery to bone and mineral deposits using bisphosphonate ligands,” Adv. Drug Deliv. Rev., 99, 12-27 (2016). doi:10.1016/j.addr.2015.10.005

L.E. Cole, T. Vargo-Gogola and R.K. Roeder, “Contrast-enhanced X-ray detection of microcalcifications in radiographically dense mammary tissue using targeted gold nanoparticles,” ACS Nano, 9 [9] 8923-8932 (2015). doi:10.1021/acsnano.5b02749  Press release.

A.P. Baumann, M.W. Aref, T.L. Turnbull, A.G. Robling, G.L. Niebur, M.R. Allen and R.K. Roeder, “Development of an In Vivo Rabbit Ulnar Loading Model,” Bone, 75, 55-61 (2015). 10.1016/j.bone.2015.01.022

R.J. Kane, H.E. Weiss-Bilka, M.J. Meagher, Y. Liu, J.A. Gargac, G.L. Niebur, D.R. Wagner and R.K. Roeder, “Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties,” Acta Biomaterialia, 17, 16-25 (2015). doi:10.1016/j.actbio.2015.01.031

L.E. Cole, R.D. Ross, J.M.R. Tilley, T. Vargo-Gogola and R.K. Roeder, “Gold nanoparticles as contrast agents in X-ray imaging and computed tomography,” Nanomedicine, 10 [2] 321-341 (2015). doi:10.2217/nnm.14.171

Summary of Activities/Interests

Biomaterials, Biomechanics, Materials Science, Mechanical Behavior, Nanoparticles, Scaffolds


Fighting for Better Cancer Detection

October 28, 2016

A mammogram’s ability to detect tumors at early stages has made breast cancer one of the most treatable forms of cancer. Still there are almost 50,000 missed diagnoses every year. Engineering professor Ryan K. Roeder has devised a way in which gold nanoparticles can be injected into the breast and attach to indicators of cancer, so they can be clearly seen.

ND Research Announces 2016 Internal Grant Awardees

May 4, 2016

Notre Dame Research has provided more than 35 researchers with awards from the Internal Grants Program for 2016.

Dr. Prakash Nallathamby wins Pfizer Young Investigator Poster Award

November 5, 2015

Postdoctoral Research Associate Prakash Nallathamby was awarded a Pfizer Young Investigator Poster Award during a recent retreat held by the Cancer Biology Training Consortium Symposium.

Researchers Use Nanotechnology to Fight Breast Cancer

October 9, 2015

October is Breast Cancer Awareness Month, an annual campaign to increase awareness of the disease and the importance of early detection. Researchers at the University of Notre Dame are conducting innovative research aimed at improvements in early detection by molecular imaging.

The Transformation of Cancer Imaging: From Shades of Gray to Living Color

September 30, 2015

Promising a transformation in biomedical imaging, a new technology called spectral [color] computed tomography is at work on the University of Notre Dame’s campus, where researchers are giving the phrase “in living color” a new meaning.