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Sangpil Yoon

Sangpil Yoon

Email: syoon4@nd.edu

Phone: 574-631-6510

Office: 151 Multidisciplinary Research Building

Education

PhD, Mechanical Engineering, The University of Texas at Austin, 2012

MS, Aerospace Engineering, Georgia Institute of Technology, 2004

BS, Mechanical Engineering, Yonsei University, 2002


Biography

Dr. Sangpil Yoon joined the Department of Aerospace and Mechanical Engineering in 2018. Prior to July 2018, he was a research associate in the Department of Biomedical Engineering at University of Southern California. He received his Bachelor’s degree in Mechanical Engineering from Yonsei University, Seoul Korea and Master’s degree in Aerospace Engineering from Georgia Institute of Technology. He earned his Ph.D. in Mechanical Engineering from the University of Texas at Austin. At UT-Austin, Dr. Yoon developed a technique to measure mechanical properties of soft tissue quantitatively using a laser-induced microbubble interrogated by acoustic radiation force under the direction of Professor Stanislav Emelianov. He joined Professor Kirk Shung’s lab at University of Southern California to develop ultrasonic transducers and intravascular ultrasound (IVUS) imaging system. As a postdoc fellow, he developed dual element IVUS imaging transducers to obtain both high and low frequency information from a single scan to better detect vulnerable atherosclerotic plaques. He developed ultra high frequency ultrasonic transducers for cellular applications. He studied biophysical effects of high frequency ultrasound to single cells including mechanotransduction and intracellular delivery of macromolecules. He has developed a new intracellular delivery technique using high frequency ultrasound and was awarded a Pathway to Independence Award (K99/R00) from the NIH. He is a member of IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society, Biomedical Engineering Society, and Acoustical Society of America.   

Summary of Activities/Interests

Dr. Yoon’s lab utilizes ultrasonic transducers and microfluidic chips to develop integrated device to engineer cells for patient-specific therapy. One of the main thrust is the generation of induced pluripotent stem cells (iPSCs) with no mutagenesis. A new device for the intracellular delivery of macromolecules has been developed for this purpose. Ultrasonic transducer will be developed to improve the specificity, efficiency, and throughput of intracellular delivery. The generated iPSC will be used for the treatment of neurodegenerative diseases. On the other hand, the integrated device will improve the recovery and efficiency of the isolation of viable circulating tumor cells (CTC) for the study of fundamental biophysics of metastasis and monitoring therapeutic responses. In addition to the development of integrated devices, we are also interested in combining the consequences of mechanotransduction and the outbreak of a certain disease such as cancer. Developing a novel way to stimulating specific cells using high frequency ultrasound may unveil new mechanisms of outbreak, relapse, and resistance to therapy of cancer. Molecular imaging using genetically encoded biosensors will be used for the study of mechanotransduction ion channels.   

 

Recent Publications

* Corresponding Author

Kim, M. G., Yoon*, S., Chiu, C. T., Shung, K. K., (2018). Investigation of optimized treatment conditions for acoustic-transfection technique for intracellular delivery of macromolecules. Ultrasound in Medicine and Biology, 44, 622-634.

Pan, Y., Yoon, S., Sun, J., Huang, Z., Lee, C., Allen, M., Wu, Y., Chang, Y-J., Sadelain, M., Shung, K. K., Chien, S., Wang, Y., (2018). Mechanogenetics for the remote and non-invasive control of cancer immunotherapy. Proceedings of the National Academy of Sciences,115, 992-997.

Kim, M. G., Park, J., Lim, H. G., Yoon, S., Lee, C., Chang, J. H., Shung, K. K., (2017). Label-free analysis of the characteristics of a single cell trapped by acoustic tweezers. Scientific Reports, 7, 14092.

Yoon, S., Wang, P., Peng, Q., Wang, Y., Shung, K. K., (2017). Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound. Scientific Reports, 7, 5275.

Yoon, S., Kim, M. G., Chiu, C. T., Hwang, J. Y., Kim, H. H., Wang, Y., Shung, K. K., (2016). Direct and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound. Scientific Reports, 6, 20477.

Kim, M. G., Yoon, S.*, Kim, H. H., Shung, K. K., (2016). Impedance matching network for high frequency ultrasonic transducer for cellular applications. Ultrasonics, 65, 258-267.

 

Awards

Post-doctoral Shooting Start Award - Cellular and Molecular Bioengineering, Biomedical Engineering Society     2018

Postdoc Scholar Training and Travel Award - University of Southern California     2017

NIH Pathway to Independence Award (K99/R00)     2017

Warren and Alice Meyer Scholarship in Engineering - University of Texas, Austin     2011-2012