College of Engineering
Postdoc, Massachusetts Institute of Technology, Cambridge, MA, 2014
Ph.D., University of California, San Diego, CA, 2011
M.S., Zhejiang University, Hangzhou, China, 2006
B.S., Tongji University, Shanghai, China, 2004
Zhangli Peng got his Ph.D. in Structural Engineering from the University of California San Diego under the supervision of Qiang Zhu, and carried out his postdoctoral research in Subra Suresh and Ming Dao's group in the Massachusetts Institute of Technology. His main research areas are multiscale/multiphysics modeling, cell biomechanics/biophysics, red blood cells, and diagnostic microfluidics. Specifically, the goal of his group is to investigate how molecular mutations influence the cell-microenvironment interactions in the living bodies (in vivo) and artificial devices (in vitro), and to understand the mechanisms of related diseases such as hematologic disorders, malaria, and cancer metastasis. In pursuit of this goal, the objective of his group is to integrate atomistic-based simulations such as molecular dynamics (MD) and dissipative particle dynamics (DPD) with continuum-based modeling approaches such as finite element method (FEM) and boundary element method (BEM) to model the cell-microenvironment interactions starting from the molecular scales, and to work closely with experimental collaborators for validations and hypothesis testing. His group is also applying computational modeling to help develop mechanical-based, acoustic-based, and electric-based microfluidics for disease diagnostics. In addition, he also studied several kinds of bio-inspired structures, including a flow energy harvester of flapping foils inspired by fish swimming, artificial nacre shells, and tensegrity structures.
Igor V. Pivkin*, Zhangli Peng*, George Em Karniadakis, Pierre A Buffet, Ming Dao, and Subra Suresh. Biomechanics of red blood cells in human spleen and consequences for physiology and disease. Proceedings of the National Academy of Sciences of the U.S.A., 113:7804–7809, doi:10.1073/pnas.1606751113, 2016. (* contributed equally).
Yan Bao, Dai Zhou, J.J. Tao, Zhangli Peng, H.B. Zhu, Z.L. Sun, and H.L. Tong, Dynamic interference of two anti-phase flapping foils in side-by-side arrangement in an incompressible flow. Accepted.
Szu-Pei Fu, Zhangli Peng, Hongyan Yuan,R. Kfoury, and Y.-N. Young, Lennard-Jones type pair-potential method for coarse-grained lipid bilayer membrane simulations in LAMMPS. Computer Physics Communications, 210:193–203, 2017.
Zhangli Peng, On-Shun Pak, Zhe Feng, Allen Liu, and Yuan-Nan Young. On the gating of mechanosensitive channels by fluid shear stress. Acta Mechanica Sinica, 2016. DOI 10.1007/s10409-016-0606-y
Alexandra Witthoft, Alireza Yazdani, Zhangli Peng, Chiara Bellini, Jay D. Humphrey and George Em Karniadakis. A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall. Journal of The Royal Society Interface, DOI: 10.1098/rsif.2015.0964, 2016.
Zhangli Peng, Yeng-Long Chen, Huijie Lu, Zehao Pan, Hsueh-Chia Chang. Mesoscale simulations of two model systems in biophysics: from red blood cells to DNAs. Computational Particle Mechanics, 4:339-357, 2015
Peng Li, Zhangming Mao, Zhangli Peng, Lanlan Zhou, Yuchao Chen , Po-Hsun Huang , Cristina I. Truica, Joseph J. Drabick, Wafik S. El-Deiry, Ming Dao, Subra Suresh, and Tony Jun Huang. Acoustic Separation of Circulating Tumor Cells. Proceedings of the National Academy of Sciences of the U.S.A. 112:4970–4975, 2015
Zhangli Peng, Sara Salehyar and Qiang Zhu. Stability of the Tank Treading Modes of Erythrocytes and Its Dependence on Cytoskeleton Reference States. Journal of Fluid Mechanics,771:449–467, 2015
Xiaoyun Ding*, Zhangli Peng*, Sz-Chin Steven Lin, Michela Geri, Sixing Li, Peng Li, Yuchao Chen, Ming Dao, Subra Suresh and Tony Jun Huang. Cell Separation Using Tilted-Angle Standing Surface Acoustic Waves. Proceedings of the National Academy of Sciences of the U.S.A.,111:12992–12997, 2014 (* contributed equally).
Xuejin Li, Zhangli Peng, Huai Lei, Ming Dao, and George Em Karniadakis. Probing the RBC dynamics, rheology and mechanics with the two component cell model. Philosophical Transactions of the Royal Society A. 372:2021,2014
Zhangli Peng, Adel Mashayekh, and Qiang Zhu. Erythrocyte Responses in Low Shear Rate Flows - Effects of Non-biconcave Stress-free State in Cytoskeleton. Journal of Fluid Mechanics, 742:96-118, 2014
Zhangli Peng, Xuejin Li, Igor V. Pivkin, Ming Dao, George Em Karniadakis, and Subra Suresh. Lipid bilayer and cytoskeletal interactions in a red blood cell. Proceedings of the National Academy of Sciences of the U.S.A., 110:13356-13361, 2013
Zhangli Peng, and Qiang Zhu. Deformation of the erythrocyte cytoskeleton in tank treading motions. Soft Matter, 9:7617-7627, 2013
HeeSu Byun, Timothy R. Hillman, John M. Higgins, Monica Diez-Silva, Zhangli Peng, Ming Dao, Ramachandra R. Dasari, Subra Suresh, and YongKeun Park. Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient. Acta Biomaterialia, 8:4130-4138, 2012
Mythili Aingaran*, Rou Zhang*, Sue Law*, Zhangli Peng*, Evan Meyer, Monica Diez-Silva, Christof Gruering, Luis Ibanez, Tobias Spielmann, Chwee Teck Lim, Subra Suresh, Ming Dao and Matthias Marti. Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum. Cellular Microbiology, 14:983-993, 2012. (* contributed equally, Featured as Editor’s choice)
Zhangli Peng, Robert J. Asaro, and Qiang Zhu. Multiscale modelling of erythrocytes in Stokes flow. Journal of Fluid Mechanics, 686: 299-337, 2011.
Jiddu Bezares, Zhangli Peng, Robert J. Asaro, and Qiang Zhu. Macromolecular structure and viscoelastic response of the organic framework of nacre in Haliotis rufescens: a perspective and overview. Theoretical and Applied Mechanics, 38: 75-106, 2011
Zhangli Peng, Robert J. Asaro, and Qiang Zhu. Multiscale modeling of erythrocyte membranes. Physical Review E , 81: 031904, 2010
Zhangli Peng and Qiang Zhu. Energy harvesting through flow-induced oscillations of a foil. Physics of Fluids, 21: 123602, 2009
Qiang Zhu and Zhangli Peng. Mode coupling and flow energy harvesting by a flapping foil. Physics of Fluids, 21: 033601, 2009
Xingfei Yuan, Zhangli Peng, Shilin Dong, and Baojun Zhao. A new tensegrity module - “Torus”. Advances in Structural Engineering, 11: 243-251, 2008
Summary of Activities/Interests
Multiscale/Multiphysics/Multicomponent Modeling; Cell Biomechanics/Biophysics; Red Blood Cells; Cell-Microenvironment Interactions; Microfluidics and Medical Diagnosis; Malaria; Sickle Cell Disease; Cancer Metastasis; Energy Harvesting by Flapping Foils; Tensegrity; Nacre