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Zhangli Peng

Zhangli Peng


Phone: 574-631-6676

Office: 369 Fitzpatrick Hall


Postdoc, Massachusetts Institute of Technology, Cambridge, MA, 2014

Ph.D., University of California, San Diego, CA, 2011

M.S., Zhejiang University, Hangzhou, China, 2006

B.S., Tongji University, Shanghai, China, 2004


Zhangli Peng got his Ph.D. in Structural Engineering from the University of California San Diego under the supervision of Qiang Zhu, and carried out his postdoctoral research in Subra Suresh and Ming Dao's group in the Massachusetts Institute of Technology. His main research areas are multiscale/multiphysics modeling, cell biomechanics/biophysics, red blood cells, and diagnostic microfluidics. Specifically, the goal of his group is to investigate how molecular mutations and alternations influence the cell-microenvironment interactions in microcirculation and microfluidics, and to understand the mechanisms of related diseases such as hematologic disorders, malaria, and cancer metastasis. In pursuit of this goal, the objective of his group is to integrate atomistic-based simulations such as molecular dynamics (MD) and coarse-grained dissipative particle dynamics (DPD) with continuum-based modeling approaches such as finite element method (FEM) and boundary element method (BEM) to model the cell-microenvironment interactions starting from the molecular scales, and to work closely with experimental collaborators for validations and hypothesis testing. His group is also applying multiphysics modeling to help develop mechanical-based, acoustic-based, thermal-based, and electric-based microfluidics/nanofluidics for disease diagnostics. In addition, he also studied several kinds of bio-inspired structures, including a flow energy harvester of flapping foils inspired by fish swimming, artificial nacre shells, and tensegrity structures.

Recent Publications:

Huijie Lu and Zhangli Peng. Boundary integral simulations of a red blood cell squeezing through a submicron slit under prescribed inlet and outlet pressuresPhysics of Fluids, 31, 031902 (2019), featured as Editor’s choice.

Sebastian Sensale, Zhangli Peng and H.-C. Chang. Acceleration of DNA Melting Kinetics Using Alternating Electric Fields, Journal of Chemical Physics,  2018.

Xuejin Li, Huijie Lu, and Zhangli Peng, Continuum- and Particle-based Modeling of Human Red Blood Cells. Handbook of Materials Modeling - Applications: Current and Emerging Materials, Edition: 4, Chapter: 11 1-16, Springer, 2018

Sebastian Sensale, Zhangli Peng and H.-C. Chang. Kinetic theory for DNA melting with vibrational entropy, Journal of Chemical Physics, 147:135101. 2017.

Yan Bao, Dai Zhou, J.J. Tao, Zhangli Peng, H.B. Zhu, Z.L. Sun, and H.L. TongDynamic interference of two anti-phase flapping foils in side-by-side arrangement in an incompressible flow. Physics of Fluids, 29:033601, 2017

Szu-Pei Fu, Zhangli Peng, Hongyan Yuan,R. Kfoury, and Y.-N. Young, Lennard-Jones type pair-potential method for coarse-grained lipid bilayer membrane simulations in LAMMPS. Computer Physics Communications, 210:193–203, 2017.

Igor V. Pivkin*, Zhangli Peng*, George Em Karniadakis, Pierre A Buffet, Ming Dao, and Subra Suresh. Biomechanics of red blood cells in human spleen and consequences for physiology and disease. Proceedings of the National Academy of Sciences of the U.S.A., 113:7804–7809, doi:10.1073/pnas.1606751113, 2016. (* contributed equally).

Zhangli Peng, On-Shun Pak, Zhe Feng, Allen Liu, and Yuan-Nan Young. On the gating of mechanosensitive channels by fluid shear stress. Acta Mechanica Sinica, . DOI 10.1007/s10409-016-0606-y, 2016

Alexandra Witthoft, Alireza Yazdani, Zhangli Peng, Chiara Bellini, Jay D. Humphrey and George Em Karniadakis. A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall. Journal of The Royal Society Interface, DOI: 10.1098/rsif.2015.0964, 2016.

Zhangli Peng, Yeng-Long Chen, Huijie Lu, Zehao Pan, Hsueh-Chia Chang. Mesoscale simulations of two model systems in biophysics: from red blood cells to DNAs. Computational Particle Mechanics, 4:339-357, 2015

Peng Li, Zhangming Mao, Zhangli Peng, Lanlan Zhou, Yuchao Chen , Po-Hsun Huang , Cristina I. Truica, Joseph J. Drabick, Wafik S. El-Deiry, Ming Dao, Subra Suresh, and Tony Jun Huang. Acoustic Separation of Circulating Tumor Cells. Proceedings of the National Academy of Sciences of the U.S.A. 112:4970–4975, 2015

Zhangli Peng, Sara Salehyar and Qiang Zhu. Stability of the Tank Treading Modes of Erythrocytes and Its Dependence on Cytoskeleton Reference States. Journal of Fluid Mechanics,771:449–467, 2015

Xiaoyun Ding*, Zhangli Peng*, Sz-Chin Steven Lin, Michela Geri, Sixing Li, Peng Li, Yuchao Chen, Ming Dao, Subra Suresh and Tony Jun Huang. Cell Separation Using Tilted-Angle Standing Surface Acoustic Waves. Proceedings of the National Academy of Sciences of the U.S.A.,111:12992–12997, 2014 (* contributed equally).

Xuejin Li, Zhangli Peng, Huai Lei, Ming Dao, and George Em Karniadakis. Probing the RBC dynamics, rheology and mechanics with the two component cell model. Philosophical Transactions of the Royal Society A. 372:2021,2014

Zhangli Peng, Adel Mashayekh, and Qiang Zhu. Erythrocyte Responses in Low Shear Rate Flows - Effects of Non-biconcave  Stress-free State in Cytoskeleton. Journal of Fluid Mechanics, 742:96-118, 2014 

Zhangli Peng, Xuejin Li, Igor V. Pivkin, Ming Dao, George Em Karniadakis,  and Subra Suresh. Lipid bilayer and cytoskeletal interactions in a red blood cell. Proceedings  of the  National  Academy  of Sciences  of the U.S.A., 110:13356-13361, 2013

Zhangli Peng, and Qiang Zhu. Deformation of the erythrocyte cytoskeleton in tank treading motions. Soft  Matter, 9:7617-7627, 2013

HeeSu Byun, Timothy R. Hillman, John M. Higgins, Monica Diez-Silva, Zhangli Peng, Ming Dao, Ramachandra R. Dasari, Subra Suresh, and YongKeun Park.  Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient. Acta Biomaterialia, 8:4130-4138, 2012

Mythili Aingaran*,  Rou Zhang*, Sue Law*, Zhangli Peng*, Evan Meyer, Monica Diez-Silva, Christof Gruering, Luis Ibanez, Tobias Spielmann, Chwee Teck Lim, Subra Suresh, Ming Dao and Matthias Marti. Host cell deformability  is linked to transmission in the human malaria parasite Plasmodium falciparum. Cellular Microbiology, 14:983-993, 2012. (contributed equally,  featured as Editor’s choice.)

Zhangli Peng, Robert J. Asaro, and Qiang Zhu. Multiscale modelling of erythrocytes in Stokes flow. Journal of Fluid Mechanics, 686: 299-337, 2011.

Jiddu Bezares, Zhangli Peng, Robert J. Asaro, and Qiang Zhu. Macromolecular structure and viscoelastic  response of the organic framework of nacre in Haliotis rufescens: a perspective and overview. Theoretical  and Applied Mechanics, 38: 75-106, 2011

Zhangli Peng, Robert J. Asaro, and Qiang Zhu.  Multiscale modeling of erythrocyte membranes. Physical Review E , 81: 031904, 2010

Zhangli Peng and Qiang Zhu. Energy harvesting through flow-induced oscillations of a foil. Physics of Fluids, 21: 123602, 2009

Qiang Zhu and Zhangli Peng. Mode coupling and flow energy harvesting by a flapping foil. Physics of Fluids, 21: 033601, 2009

Xingfei Yuan, Zhangli Peng, Shilin Dong, and Baojun Zhao. A new tensegrity module - “Torus”. Advances in Structural Engineering, 11: 243-251, 2008

Summary of Activities/Interests

Computational Science and Engineering; Multiscale Modeling; Physics of Molecules, Cells, Tissues, and Soft Matters; Red Blood Cells; Primary Cilia; DNA/RNA; Microfluidics/Nanofluidics; Coupling Finite Elements and Boundary Elements; Coarse-Graining and Dissipative Particle Dynamics; Molecular Dynamics; Energy Harvesting by Flapping Foils; Tensegrity; Nacre


Researchers Work to Unlock Clues to How Cells Move through the Body

August 14, 2017

A team of researchers, led by Notre Dame's Zhangli Peng and co-investigator Juan del Alamo of the University of California at San Diego, is studying the transmigration of red blood cells through inter-endothelial slits in the spleen, the narrowest point in the body through which these cells travel, to provide important clues in a variety of physiological and pathological processes and potentially impact the design of artificial organs and other biomedical devices.