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Zachary Schultz

Zachary D. Schultz


Phone: 574-631-1853

Office: 224 Nieuwland Science


Ph.D, University of Illinois at Urbana-Champagne, 2005

B.S., The Ohio State University


NRC Postdoc Fellow- National Institute of Standards and Technology,  2005-2007
Research Fellow- National Institute of Diabetes and Digestive and Kidney Diseases, NIH 2007-2009
Assistant Professor- University of Notre Dame, concurrent 


Asiala, S.M., Schultz, Z.D. “Label-Free In Situ Detection of Individual Macromolecular Assemblies by Surface Enhanced Raman Scattering” Chemical Communications, IN PRESS, DOI: 10.1039/C2CC37268A.

Alexander, K.D., Schultz, Z.D. “Tip-Enhanced Raman Detection of Antibody Conjugated Nanoparticles on Cellular Membranes”, Analytical Chemistry, 2012, 84(17), 7408-7414, DOI: 10.1021/ac301739k

Featured: C&EN News, Science & Technology Concentrate, Aug. 27, 2012

Marr, J.M., Li, F., Petlick, A.R., Schafer, R., Hwang,C-T, Chabot, A., Ruggiero,S.T., Tanner, C.E., Schultz, Z.D. “The Role of Lateral Tension in Calcium induced DPPS Vesicle Rupture”, Langmuir, 28(32), 2012, 11874-11880, DOI: 10.1021/la301976s

Asiala, S.M., Schultz, Z.D. “Characterization of Hotspots in a Highly Enhancing SERS Substrate”, Analyst, 136(21), 2011, 4472-4479, DOI: 10.1039/C1AN15432J

Schultz, Z.D., Levin I.W. “Vibrational Spectroscopy of Biomembranes” Annual Reviews of Analytical Chemistry, 4, 2011, 343-366, DOI: 10.1146/annurev-anchem-061010-114048

Schultz, Z.D. "Raman Spectroscopic Imaging of Cholesterol and Docosahexaenoic Acid Distribution in the Retinal Rod Outer Segment." Australian Journal of Chemistry, 64(5), 2011, 611-616, Invited Article. DOI: 10.1071/CH11019

Carrier, S.L., Kownacki, C.M., Schultz, Z.D.* “Protein-Ligand Binding Investigated by a Single Nanoparticle-TERS Approach.” Chemical Communications, 47(7), 2011, 2065-2067, DOI: 10.1039/C0CC05059H


NIH Pathway to Independence Award, 2008

Summary of Activities/Interests

Research in the Schultz lab focuses on understanding how the spatial organization of molecules affects their behavior. We utilize laser spectroscopy, including nonlinear spectroscopic methods, and also spectroscopic imaging modalities such as Raman near-field scanning optical microscopy, which is capable of vibrational spectroscopic imaging with a spatial resolution of tens of nanometers.

One area where molecular organization plays an important role is the behavior observed in cellular membranes. We are interested in understanding how the organization of molecules in biomembranes impact biomedical issues such as dysfunctional cellular pathways that cause disease, viral and bacterial infection, and drug delivery. These interactions occur at the nanometer length scale, necessitating the development of new methods.

A second area involves understanding how chemical heterogeneity affects reactivity. Bi-metallic nanoparticles, used as catalysts in fuel cells, often show chemical activity that the individual components do not. Understanding the molecular interactions associated with these composite materials is important for developing new sources of energy. Methods being developed in our lab have the potential to offer new insights into these processes.