Category: Research and Innovation

A pipette places drops of green liquid onto a microscope slide containing a small device

Heart-on-a-chip device identifies youth-enhancing “cocktail” to repair old hearts

The heart is a pump that wears out over time—that, at least, was the prevailing view. New research has shown that the heart’s aging results from changes in intercellular communications, which tell heart cells, sometimes even healthy ones, to stiffen and break down. By decoding these complex …

Katharine White and Donny Hanjaya-Putra

Notre Dame researchers uncover the molecular driving force behind hallmark of aggressive, metastatic cancers

To invade healthy tissues and continue growing, aggressive cancers mimic and circumvent the body’s native piping system of veins and arteries. Through this process, known as vasculogenic mimicry (VM), tumor cells form fluid-conducting channels that transport blood, oxygen, and nutrients directly …

A young woman looks at a microscope slide that has a dab of clear gel in the middle of it

3D-bioprinted model offers new way to study and treat obesity-related heart disease

Heart disease is the leading cause of death among people with obesity, a condition affecting one in eight people worldwide. Studies show that fat around the heart can fuel inflammation, damage heart muscle cells, disrupt heart rhythm and increase the risk of heart failure, but the precise …

Glowing orange light waves travel along and bend around a geometric, triangular-patterned surface, illustrating researchers guiding light through a structured material to form a 6G terahertz “super-antenna.”

Using geometry, researchers coax light into 6G terahertz “super-antenna”

Engineers have long focused their efforts on confining signal-carrying photons to chips. Every photon that escapes, they reasoned, is information lost. But one group of researchers has stood that paradigm on its head. By deliberately “leaking” photons into the air, they created, not the …

Two researchers in white lab coats and safety glasses work in a lab. A man in blue gloves uses a tool to transfer liquid into a small container near a multi-well plate with reddish liquid. A woman observes him, smiling softly.

Physical pressure on the brain triggers neurons’ self-destruction programming

To think, feel, talk and move, neurons send messages through electrical signals in the brain and spinal cord. This intricate communication network is built of billions of neurons connected by synapses and managed and modified by glial cells. When neurons die, this communication network is …

Nighttime city view with many lit buildings. Two industrial chimneys, one black and one white, glow red at their tops while releasing thick white smoke into the dark, cloudy sky.

New tool tracks cross-border pollution, revealing unequal distribution of risk, responsibility

Microscopic airborne particles known as PM 2.5 contribute to 100,000 premature deaths in the United States each year. A new University of Notre Dame study finds that 40 percent of these deaths can be attributed to pollution that crosses state lines, highlighting the impact of the problem and …

Four men pose in front of a projector screen.

Notre Dame-Indiana University team enters final round for Alzheimer’s Insights AI competition

More than 55 million people worldwide now live with Alzheimer’s and related dementias. Without treatments or cures, that number could rise to a staggering 152 million people by 2050. Yiyu Shi, professor of computer science and engineering at the University of Notre Dame, is co-leading a team …

The Vaisala FD70 sensor, a piece of equipment used by researchers in northern Alaska, is decorated with white string lights, red beaded garland, and red Christmas ornaments.

Shedding Light on Ice Fog in the Darkness of Polar Night

Ice fog—a curtain of tiny ice crystals suspended above the earth’s surface—reduces visibility and makes air travel treacherous. How ice fog forms and why it persists is not entirely understood, and this has led to inaccurate forecasts, particularly visibility predictions that are critical …

TIngyu Cheng, a man wearing a black top, holds a chip between his finger and thumb.

Tackling e-waste with biodegradable electronics

In 2022, according to the Global E-waste Monitor 2024, humanity produced 62 million tons of e-waste—discarded phones, printers, and other devices. By 2030, that number is projected to rise another 32%, reaching 82 million. To address this significant environmental problem, Tingyu Cheng, …

blue-gloved hands hold a white rectangular membrane

Smarter filter uses electric charges to target pollutants and recover resources 

Purifying dirty water is an age-old problem that has become more urgent as the global population grows, and water contains more and different kinds of pollutants. Over time, filters have evolved—from simple sieves that strain out sand and dirt to advanced membranes that selectively remove …